ISBN: 0-471-20200-2

TOC:

Preface (J. Wooley).

Introductory Comments (The Editors).

SECTION I: INTRODUCTION.

• What is Bioinformatics and Structural Bioinformatics (R. Altman & J. Dugan).
• Fundamentals of Protein Structure (E. Scheeff & L. Fink).
• Fundamentals of DNA and RNA Structure (S. Neidle, et al.).
• Computational Aspects of High-Throughput Crystallographic Macromolecular Structure Determination (P. Adams, et al.).
• Macromolecular Structure Determination by NMR Spectroscopy (J. Markley, et al.).
• Electron Microscopy (N. Volkmann & D. Hanein).
• Molecular Visualization (J. Tate).

  SECTION II: DATA REPRESENTATION AND DATABASES.

• The PDB Format, mmCIF Formats and Other Data Formats (J. Westbrook & P. Fitzgerald).
• The Protein Data Bank (The PDB Team).
• The Nucleic Acid Database (H. Berman, et al.).
• Other Structure Based Databases (H. Weissig & P. Bourne).

  SECTION III: COMPARATIVE FEATURES.

• Protein Structure Evolution and the SCOP Database (B. Reddy & P. Bourne).
• The CATH Domain Structure Database (C. Orengo, et al.).
• Structural Quality Assurance (R. Laskowski).
• All-Atom Contacts: A New Approach to Structure Validation (J. Richardson).
• Structure-Structure Comparison and Alignment (I. Shinadyalov & P. Bourne).

  SECTION IV: STRUCTURE AND FUNCTIONAL ASSIGNMENT.

• Secondary Structure Assignment (C. Andersen & B. Rost).
• Identifying Structural Domains in Proteins (L. Wernisch & S. Wodak).
• Inferring Protein Function from Structure (G. Bartlett, et al.).

  SECTION V: PROTEIN INTERACTIONS.

• Prediction of Protein-Protein Interactions from Evolutionary Information (A. Valencia & F. Pazos).
• Electrostatic Interactions (N. Baker & J. McCammon).

  SECTION VI: PROTEINS AS DRUG TARGETS.

• Principles and Methods of Docking and Ligand Design (J. Krumrine, et al.).
• Structural Bioinformatics in Drug Discovery (E. Fauman, et al.).

  SECTION VII: STRUCTURE PREDICTION.

• The CASP Experiment and Its Findings (TBN).
• Homology Modeling (E. Krieger, et al.).
• Fold Recognition Methods (A. Godzik).
• Ab Initio Methods (D. Chivian, et al.).
• Prediction in 1D: Secondary Structure, Membrane Helices, and Accessibility (B. Rost).

  SECTION VIII: THE FUTURE.

• Structural Genomics (S. Burley & J. Bonanno).
• Epilogue.

Hardcover, 649 Pages; February 2003; John Wiley