Throughout
the foreseeable future, research in medicine, molecular biology, and biotechnology
will be dominated by scientific advances resulting from the Human Genome
Project. Knowledge of genomes will elucidate disease patterns and promise
improved and personalized treatments. Food and drug development will be
revolutionized by focused manipulation of genes and biochemical processes.
Researchers will begin to construct metabolic pathways from scratch. A
true understanding of genetic and metabolic function and design will depend
on mathematical and computational methods for analyzing biochemical systems.
It will require new ways of thinking and novel approaches of integrative
analysis. This book teaches biochemists and molecular biologists the use
of modern computational methods for the analysis of complex biomedical
systems without assuming more than a modest background in mathematics.
The book begins with representations of biochemical systems, provides
guidelines for setting up models, discusses in detail mathematical and
computational methods of parameter estimation and model analysis, and
ultimately connects to the modern literature with four detailed case studies.
Every step is illustrated with examples and explored with accompanying
software.
Paperback: 544 pages;
September 4, 2000; Cambridge University Press; Book and CD-ROM edition
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