The Pacific Northwest National Laboratory (PNNL) is one of nine U.S. Department of Energy (DOE) national laboratories. PNNL often partners with universities to collaborate on scientific research. This talk will present DOE's aims in systems biology and bioinformatics research, and give an overview of such efforts at PNNL in particular, focusing on research within the Biomolecular Systems Initiative (BSI), which is a multidisciplinary program to understand complex biological systems from a systems perspective, and concentrating on PNNL's Computational Biology and Bioinformatics Group (CBBG). The aim is to generate interest in collaborations with PNNL scientists and in opportunities for student research at PNNL, and to give enough information in the brief span of the talk to facilitate follow-up contact. Specific areas to be covered include: (1) DOE's Genomics:GTL program and PNNL's plans for the Whole Proteome Analysis Facility, (2) the PNNL and Oak Ridge National Laboratory collaboration for the joint GTL Center for Molecular and Cellular Systems, (3) a sampling of current research projects within the CBBG, focusing on integrated data analysis (Computational Cell Environment and related projects) and inference of genetic regulatory networks, and (4) student research opportunities through PNNL's Office of Fellowship Programs (OFP) and the DOE Science Undergraduate Laboratory Internship (SULI) Program. References: 1) Frazier, M. E., et al.