Regulatory and Systems Genomics 2020 will include an abstract submissions track for a Special Session of Cancer Systems. We welcome submissions on computational and experimental advances regulatory and systems genomics in immunology. Topics include but are not limited to: immunological regulatory programs and signaling pathways, genetic and non-genetic sources of self/non-self identification, precision epitope identification and targeting, and immune cell regulation. The session will include presentations from keynote speakers as well as talks from selected abstracts. This special session is sponsored by the Research Center for Cancer Systems Immunology at Memorial Sloan Kettering Cancer Center, an NCI-funded Cancer Systems Biology Consortium (CSBC) Center.