What is Bioinformatics?

Bioinformatics generally applies computer science to solve biological problems. However, the field is interdisciplinary and constantly developing, so it is difficult to answer this question in one sentence. 2013, 2012 and 2010-2011 articles have been archived. Earlier Archives are available.

Introductory links

General References

Advanced Topics

  • Suwa M.
    Bioinformatics Tools for Predicting GPCR Gene Functions.
    Adv Exp Med Biol. 2014;796:205-24. PubMed abstract

  • Allmer J.
    Computational and Bioinformatics Methods for MicroRNA Gene Prediction.
    Methods Mol Biol. 2014;1107:157-75. PubMed abstract

  • Ning L, Liu G, Li G, Hou Y, Tong Y, He J.
    Current Challenges in the Bioinformatics of Single Cell Genomics.
    Front Oncol. 2014 Jan 27;4:7. PubMed abstract

  • Marz M, Beerenwinkel N, Drosten C, Fricke M, Fricke M, Frishman D, Hofacker IL, Hoffmann D, Middendorf M, Rattei T, Stadler PF, Töpfer A.
    Challenges in RNA Virus Bioinformatics.
    Bioinformatics. 2014 Mar 3. PubMed abstract

  • Chang CC, Tey BT, Song J, Ramanan RN.
    Towards more accurate prediction of protein folding rates: a review of the existing web-based bioinformatics approaches.
    Brief Bioinform. 2014 Mar 11. PubMed abstract

  • Ryu SY.
    Bioinformatics tools to identify and quantify proteins using mass spectrometry data.
    Adv Protein Chem Struct Biol. 2014;94:1-17. PubMed abstract

  • Jung S, Main D.
    Genomics and bioinformatics resources for translational science in Rosaceae.
    Plant Biotechnol Rep. 2014;8:49-64. PubMed abstract

  • Gorodkin J, Hofacker IL, Ruzzo WL.
    Concepts and introduction to RNA bioinformatics.
    Methods Mol Biol. 2014;1097:1-31. PubMed abstract

  • Tafer H.
    Bioinformatics of siRNA Design.
    Methods Mol Biol. 2014;1097:477-90. PubMed abstract

  • Tang H, Mayampurath A, Yu CY, Mechref Y.
    Bioinformatics protocols in glycomics and glycoproteomics.
    Curr Protoc Protein Sci. 2014 Apr 1;76:2.15.1-7. PubMed abstract

  • Acosta-Martin AE, Lane L.
    Combining bioinformatics and MS-based proteomics: clinical implications.
    Expert Rev Proteomics. 2014 Apr 10. PubMed abstract

  • Guffanti A, Simchovitz A, Soreq H.
    Emerging bioinformatics approaches for analysis of NGS-derived coding and non-coding RNAs in neurodegenerative diseases.
    Front Cell Neurosci. 2014 Mar 27;8:89. PubMed abstract

  • Li S, Kang L, Zhao XM.
    A Survey on Evolutionary Algorithm Based Hybrid Intelligence in Bioinformatics.
    Biomed Res Int. 2014;2014:362738. Epub 2014 Mar 6. PubMed abstract

  • Backofen R, Amman F, Costa F, Findeiß S, Richter AS, Stadler PF.
    Bioinformatics of prokaryotic RNAs.
    RNA Biol. 2014 Apr 2;11(5). PubMed abstract

  • Vaudel M, Barsnes H, Martens L, Berven FS.
    Bioinformatics for proteomics: opportunities at the interface between the scientists, their experiments, and the community.
    Methods Mol Biol. 2014;1156:239-48. PubMed abstract

  • Arora PK, Bae H.
    Integration of bioinformatics to biodegradation.
    Biol Proced Online. 2014 Apr 27;16:8. PubMed abstract

  • Willet CE, Wade CM.
    From the Phenotype to the Genotype via Bioinformatics.
    Methods Mol Biol. 2014;1168:1-16. PubMed abstract

  • Allcock RJ.
    Production and analytic bioinformatics for next-generation DNA sequencing.
    Methods Mol Biol. 2014;1168:17-29. PubMed abstract

  • De R, Bush WS, Moore JH.
    Bioinformatics Challenges in Genome-Wide Association Studies (GWAS).
    Methods Mol Biol. 2014;1168:63-81. PubMed abstract

  • Doyle MA, Li J, Doig K, Fellowes A, Wong SQ.
    Studying cancer genomics through next-generation DNA sequencing and bioinformatics.
    Methods Mol Biol. 2014;1168:83-98 PubMed abstract

  • Passetti F, Jorge NA, Durham A.
    Using Bioinformatics Tools to Study the Role of microRNA in Cancer.
    Methods Mol Biol. 2014;1168:99-116. PubMed abstract

  • Alawieh A, Sabra Z, Nokkari A, El-Assaad A, Mondello S, Zaraket F, Fadlallah B, Kobeissy FH.
    Bioinformatics approach to understanding interacting pathways in neuropsychiatric disorders.
    Methods Mol Biol. 2014;1168:157-72. PubMed abstract

  • Sintchenko V, Roper MP.
    Pathogen genome bioinformatics.
    Methods Mol Biol. 2014;1168:173-93. PubMed abstract

  • Petrey D, Honig B.
    Structural bioinformatics of the interactome.
    Annu Rev Biophys. 2014 May 6;43:193-210. PubMed abstract

  • Lagunin AA, Goel RK, Gawande DY, Pahwa P, Gloriozova TA, Dmitriev AV, Ivanov SM, Rudik AV, Konova VI, Pogodin PV, Druzhilovsky DS, Poroikov VV.
    Chemo- and bioinformatics resources for in silico drug discovery from medicinal plants beyond their traditional use: a critical review.
    Nat Prod Rep. 2014 Jul 22. PubMed abstract

  • Sudha G, Nussinov R, Srinivasan N.
    An overview of recent advances in structural bioinformatics of protein-protein interactions and a guide to their principles.
    Prog Biophys Mol Biol. 2014 Jul 29. pii: S0079-6107(14)00066-2. PubMed abstract

  • Yan Q.
    Translational bioinformatics approaches for systems and dynamical medicine.
    Methods Mol Biol. 2014;1175:19-34. PubMed abstract

  • Smith DR.
    Buying in to bioinformatics: an introduction to commercial sequence analysis software.
    Brief Bioinform. 2014 Sep 1 PubMed abstract

  • Dalpé G, Joly Y.
    Opportunities and challenges provided by cloud repositories for bioinformatics-enabled drug discovery.
    Drug Dev Res. 2014 Sep;75(6):393-401. PubMed abstract

  • Van Neste L, Van Criekinge W.
    We are all individuals… bioinformatics in the personalized medicine era.
    Cell Oncol (Dordr). 2014 Sep 10. PubMed abstract

  • Taher L, Pfeiffer MJ, Fuellen G.
    Bioinformatics approaches to single-blastomere transcriptomics.
    Mol Hum Reprod. 2014 Sep 19. PubMed abstract

  • Merelli I, Pérez-Sánchez H, Gesing S, D'Agostino D.
    Managing, Analysing, and Integrating Big Data in Medical Bioinformatics: Open Problems and Future Perspectives.
    Biomed Res Int. 2014;2014:134023. PubMed abstract

  • Bao R, Huang L, Andrade J, Tan W, Kibbe WA, Jiang H, Feng G.
    Review of current methods, applications, and data management for the bioinformatics analysis of whole exome sequencing.
    Cancer Inform. 2014 Sep 21;13(Suppl 2):67-82. PubMed abstract

  • Kim S.
    Recent development in bioinformatics for utilizing omics data.
    Methods. 2014 Oct 1;69(3):205-6. PubMed abstract

  • Olsen LR, Campos B, Barnkob MS, Winther O, Brusic V, Andersen MH.
    Bioinformatics for cancer immunotherapy target discovery.
    Cancer Immunol Immunother. 2014 Oct 26. PubMed abstract

  • Kerksick C, Tsatsakis AM, Hayes AW, Kafantaris I, Kouretas D.
    How Can Bioinformatics and Toxicogenomics Assist the Next Generation of Research on Physical Exercise and Athletic Performance.
    J Strength Cond Res. 2014 Oct 28. PubMed abstract

  • Johnson CH, Ivanisevic J, Benton HP, Siuzdak G.
    Bioinformatics: The Next Frontier of Metabolomics.
    Anal Chem. 2014 Nov 12. PubMed abstract

  • Liu X, Wu J, Gu F, Wang J, He Z.
    Discriminative pattern mining and its applications in bioinformatics.
    Brief Bioinform. 2014 Nov 28. pii: bbu042. PubMed abstract

  • Wu C, Ma S.
    A selective review of robust variable selection with applications in bioinformatics.
    Brief Bioinform. 2014 Dec 5. pii: bbu046. PubMed abstract

  • Kunz M, Xiao K, Liang C, Viereck J, Pachel C, Frantz S, Thum T, Dandekar T.
    Bioinformatics of cardiovascular miRNA biology.
    J Mol Cell Cardiol. 2014 Dec 5. pii: S0022-2828(14)00387-3. PubMed abstract

  • Oliver GR, Hart SN, Klee EW.
    Bioinformatics for Clinical Next Generation Sequencing.
    Clin Chem. 2015 Jan;61(1):124-135. PubMed abstract

  • Samish I, Bourne PE, Najmanovich RJ.
    Achievements and challenges in structural bioinformatics and computational biophysics.
    Bioinformatics. 2015 Jan 1;31(1):146-50. PubMed abstract

  • Ciuffi A, Mohammadi P, Golumbeanu M, di Iulio J, Telenti A.
    Bioinformatics and HIV Latency.
    Curr HIV/AIDS Rep. 2015 Jan 14. PubMed abstract

  • Stefano GB, Kream RM.
    Personalized- and one- medicine: bioinformatics foundation in health and its economic feasibility.
    Med Sci Monit. 2015 Jan 15;21:201-4. PubMed abstract

  • Chen Q, Luo H, Zhang C, Chen YP.
    Bioinformatics in Protein Kinases Regulatory Network and Drug Discovery.
    Math Biosci. 2015 Feb 2. pii: S0025-5564(15)00029-2. PubMed abstract

  • Bell TG, Kramvis A.
    Bioinformatics tools for small genomes, such as hepatitis B virus.
    Viruses. 2015 Feb 16;7(2):781-97. PubMed abstract

  • Ahmed F, Dai X, Zhao PX.
    Bioinformatics tools for achieving better gene silencing in plants.
    Methods Mol Biol. 2015;1287:43-60. PubMed abstract

  • Li L.
    The potential of translational bioinformatics approaches for pharmacology research.
    Br J Clin Pharmacol. 2015 Mar 5. PubMed abstract

  • Satpathy R, Konkimalla VB, Ratha J.
    Application of bioinformatics tools and databases in microbial dehalogenation research (a review).
    Prikl Biokhim Mikrobiol. 2015 Jan-Feb;51(1):15-23. PubMed abstract

  • Calabrese B, Cannataro M.
    Bioinformatics and Microarray Data Analysis on the Cloud.
    Methods Mol Biol. 2015 Apr 12. PubMed abstract

  • Wu D, Wang X.
    Application of clinical bioinformatics in lung cancer-specific biomarkers.
    Cancer Metastasis Rev. 2015 May 3. PubMed abstract

Links and references provided by Lynda Ellis