- Presents an historic
overview of genome biology and its achievements
- Includes topics
not covered in other books such as minimal and ancestral genomes
- Discusses the evolutionary
resilience of protein-coding genes and frequent functional convergence
at the molecular level
- Critically reviews
horizontal gene transfer and other contentious issues
- Covers comparative
virology as a somewhat overlooked foundation of modern genome science
This book provides an overview of computational analysis of genes and
genomes, and of some most notable findings that come out of this work.
Foundations of Comparative Genomics presents a historical perspective,
beginning with early analysis of individual gene sequences, to present
day comparison of gene repertoires encoded by completely sequenced genomes.
The author discusses the underlying scientific principles of comparative
genomics, argues that completion of many genome sequences started a new
era in biology, and provides a personal view on several state-of-the-art
issues, such as systems biology and whole-genome phylogenetic reconstructions.
This book is an essential reference for researchers and students in computational
biology, evolutionary biology, and genetics.
280 pages; March 30, 2007; Academic Press