Bioinformatics Algorithms: Sequence Analysis, Genome Rearrangements, and Phylogenetic Reconstruction
Bioinformatics Algorithms: Sequence Analysis, Genome Rearrangements, and Phylogenetic Reconstruction

ISBN: 1936113503

Author(s): Enno Ohlebusch, Ph.D.

Hardcover; 604 pages; 2013 edition (August 30, 2013); Oldenbusch Verlag
Purchase from www.oldenbusch-verlag.de/
Description: Powerful new techniques have revolutionized the field of molecular biology. The vast amount of DNA sequence information produced by next-generation sequencers demands new bioinformatics algorithms to analyze the data.

This book provides an introduction to algorithms and data structures that operate efficiently on strings (especially those used to represent long DNA sequences). It focuses on algorithms for sequence analysis (string algorithms), but also covers genome rearrangement problems and phylogenetic reconstruction methods.

Topics and features:
  • first unified presentation of enhanced suffix arrays
  • up-to-date overview of their applications in computer science and bioinformatics
  • special emphasis on solving large-scale problems
  • presentation of space-efficient algorithms on strings, based on the Burrows-Wheeler transform and backward search
  • comprehensive coverage of sorting by reversals
  • in-depth study of distance-based phylogenetic reconstruction algorithms
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