Phylogeny and Evolution of Human Cathepsins

Veronika Stoka1, Vito Turk2 , J. Stefan Institute;, J. Stefan Institute

Cathepsins are proteolytic enzymes of lysosomal origin. According their catalytic mechanism they can be classified as cysteine, serine or aspartic proteases. Here we show that these enzymes evolved from at least three different evolutionary origins, each of which has produced a group of peptidases with distinctive properties.