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Postdoctoral fellowship in the field of computational cancer epigenomics
German Cancer Research Center (DKFZ)
Germany-Heidelberg

Division of Cancer Epigenomics at the German Cancer Research Center (DKFZ) is searching for candidates for a postdoctoral fellowship to strengthen its computational team. The division conducts a rich and vibrant research program in epigenomics of several cancer entities, focusing on leukemias, several solid tumor types, such as prostate, breast and lung, as well as certain rare bone neoplasms. We generate a wide range of epigenetic profiles in tumors, both bulk and single-cell: including DNA methylomes, chromatin accessibility and histone modification patterns, genomic contact maps etc. Bioinformatically, we develop a novel computational methodology and user-friendly tools to enable comprehensive analysis of epigenomic data from multiple angles.

The project will involve a large integrative analysis of whole-genome DNA methylomes from several types of leukemia with the goal of deriving a wholistic interpretation of epigenomic alteration in blood cancers. We will extensively use available reference methylomes of blood cell types, e.g. those derived within the BLUEPRINT project, in order to delineate cell type heterogeneity of derived patient samples. Furthermore, we will develop computational methods for reference-free deconvolution of DNA methylomes and cell-type-of-origin identification. The goal is to delineate and generalize epigenetic alterations in leukemias in the context of hematopoietic differentiation.

Qualifications

Applicants should have a Ph.D. degree in computational biology, bioinformatics or related discipline, with a solid mathematical/computational background and proven track record of methods development for life-science applications. Fluency in one of the standard scripting languages (python, Perl or alike) as well as experience with R is preferred, but not a must, should the candidate be proficient in any other general domain-specific languages (e.g., C/C++, Java or Matlab). We expect basic knowledge of Unix-like operating systems and respective command line interface (bash scripting) and ability to work in typical HPC environment setups (schedulers, cloud environments etc.). Previous experience with epigenomic data or cancer research applications is an advantage.

Job Information

Start Dates: ASAP

Duration: Temporary

Status: Open

Contact Information

German Cancer Research Center (DKFZ)
Cancer Epigenomics
Pavlo Lutsik; Susanna Grenner
p.lutsik@dkfz.de
https://www.dkfz.de/en/CanEpi

How To Apply:

All potential candidates should take part in the ongoing round of the DKFZ Postdoc selection program (https://www.dkfz.de/en/postdoc-program/index.html). More detailed information about the project can be requested from Dr. Pavlo Lutsik. You can find further information about the Division of Epigenomics at https://www.dkfz.de/en/CanEpi.