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Results

July 20, 2025
18:30-19:30
Invited Presentation: Extending AlphaFold to make predictions across the universe of biomolecular interactions
Track: Distinguished Keynotes

Room: 01A

Authors List: Show

  • John Jumper

Presentation Overview:Show

The high accuracy of AlphaFold 2 in predicting protein structures and protein-protein interactions raises the question of how to extend the success of AlphaFold to general biomolecular modeling, including protein-nucleic and protein-small molecule structure predictions as well as the effects of post-translational modification. In this talk, I will discuss our latest work on AlphaFold 3 to develop a single deep learning system that makes accurate predictions across these interaction types, as well as examine some of the remaining challenges in predicting the universe of biologically-relevant protein interactions.