| Small GTPases in Membrane Processes: Trafficking, Autophagy and Disease Conference | |
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United States - VA - Leesburg |
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| Hosted by: | FASEB |
| Venue: | The National Conference Center |
| Dates: | Sep 23, 2018 through Sep 28, 2018 |
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Description |
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| "The fields of membrane trafficking in general and autophagy in particular got the Nobel Prize for Medicine in 2013 and 2016, respectively. The next important question of these fields, how membrane structure and function are regulated, is highly relevant to human health and disease. The molecular components involved in this regulation and their mechanisms of action, are currently only poorly understood. Small GTPases from the Arf, Arl, Rab and Rag subfamilies regulate traffic, proteostasis, membrane dynamics, signaling and lipid metabolism. Over the years, progress on different subfamilies of small GTPases has been enormous. The inclusion of Rag GTPases in the 2016 FASEB conference reflected the necessity of our field to consider such rapidly evolving fields. In the current meeting, we added the Ras sub-family and would we welcome other relevant additions. All these GTPase subfamilies together with their auxiliary factors play important roles in human health, from inherited disorders to complex diseases. Regulation of membrane-associated processes is a very dynamic field relevant to various disciplines, from neuroscience to cell and developmental biology, and uses multiple approaches, from structural biology to biophysics. The widespread current interest in this field is evident from the rapidly increasing number of published papers and from its attraction to new investigators who bring in new approaches. For example, in addition to the traditional approaches of cell and molecular biology including sophisticated microcopy, recently the following approaches have been introduced to the field: structure-function, physico-chemical analyses, and mathematical modeling. Because we think the field will benefit from interdisciplinary approaches, our goal is to include various emerging approaches in the next meeting." |
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| Additional Information | |
| Event URL: | http://www.faseb.org/src/micro/Site/GTPas/Home.aspx |
| ISCB Member Discount: | None |
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