Non-coding RNA data analysis Tutorials
Non-coding RNA (ncRNA) are transcripts not translated into proteins. ncRNA genes include highly abundant and functionally important RNAs such as transfer RNA (tRNA) and ribosomal RNA (rRNA), as well as RNAs such as snoRNAs, microRNAs, siRNAs, snRNAs, exRNAs, piRNAs and the long ncRNAs. The number of ncRNAs encoded within the genomes is unknown, however recent transcriptomics and bioinformatics studies suggest the existence of over twenty thousands such genes. New high throughput sequencing technologies (NGS) have dramaticly changed the scale of ncRNA studies. However the analysis of such data is still in development and significant computational biology knowledge is required for biologically relevant interpretation.
The data analysis of ncRNA is divided into two main directions:
i) discovery of known and unknown ncRNA and
ii) discovery of the target genes of these ncRNAs.
The tutorial will cover both aspects, offering hands-on on ncRNA discovery using real dataset to find known and unknown ncRNA such as miRNA, piRNA, lncRNA etc but also an extensive hands-on on finding potential target genes for miRNA either using databases with pre-calculated targets or run algorithms to search for new target genes. Last is important for participants working on non-model systems where no such databases of pre-calculated targets are available.
Click here to download the schedule of the Tutorials.
Teachers:
- Artemis HATZIGEORGIOU, Biomedical Sciences Research Center ‘Alexander Fleming’, Vari GR
- Andreas GISEL, Institute of Biomedical Technologies, National Research Council, Bari IT
- Erik BONGCAM-RUDLOFF, SLU-Global Bioinformatics Centre, Uppsala SE
The maximum number of attendees is 25 and will be assigned on a first-come first-served basis. The list of participants in the tutorials is already full, as well as the tutorials waiting list.
Sponsor: EU FP7 ALLBIO project