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What is Bioinformatics?

Whats BI 2012

Bioinformatics generally applies computer science to solve biological problems. However, the field is interdisciplinary and constantly developing, so it is difficult to answer this question in one sentence. 2010-2011 articles have been archived. Earlier Archives are available.

General References

  • PLos Computational Biology
    The Roots of Bioinformatics (2011) PLoS Collections.
    http://www.ploscollections.org/rootsofbioinformatics


  • Attwood TK, Gisel A, Eriksson N-E, Bongcam-Rudloff, E.
    Concepts, historical milestones and the central place of bioinformatics in modern biology: a European perspective.
    In Bioinformatics - Trends and Methodologies, M.A.Mahdavi Ed., Intech Online Publishers, November 2011
    Intech Online Chapter

Selected Topics

  • Eichler GS.
    Bioinformatics/Biostatistics: microarray analysis.
    Methods Mol Biol. 2012;823:347-58. PubMed abstract

  • Tucker A, Duplisea D.
    Bioinformatics tools in predictive ecology: applications to fisheries.
    Philos Trans R Soc Lond B Biol Sci. 2012 Jan 19;367(1586):279-90. PubMed abstract

  • Nitsche BM, Ram AF, Meyer V.
    The use of open source bioinformatics tools to dissect transcriptomic data.
    Methods Mol Biol. 2012;835:311-31. PubMed abstract

  • Allmer J.
    Existing bioinformatics tools for the quantitation of post-translational modifications.
    Amino Acids. 2012 Jan;42(1):129-38. PubMed abstract

  • Capriotti E, Nehrt NL, Kann MG, Bromberg Y.
    Bioinformatics for personal genome interpretation.
    Brief Bioinform. 2012 Jan 13. PubMed abstract

  • Scholz MB, Lo CC, Chain PS.
    Next generation sequencing and bioinformatic bottlenecks: the current state of metagenomic data analysis.
    Curr Opin Biotechnol. 2012 Feb;23(1):9-15. PubMed abstract

  • Ram PT, Mendelsohn J, Mills GB.
    Bioinformatics and systems biology.
    Mol Oncol. 2012 Feb 17. PubMed abstract

  • Sugimoto M, Kawakami M, Robert M, Soga T, Tomita M.
    Bioinformatics Tools for Mass Spectroscopy-Based Metabolomic Data Processing and Analysis.
    Curr Bioinform. 2012 Mar;7(1):96-108. PubMed abstract

  • Wu D, Rice CM, Wang X.
    Cancer bioinformatics: A new approach to systems clinical medicine.
    BMC Bioinformatics. 2012 May 1;13(1):71. PubMed abstract

  • Altman RB.
    Translational Bioinformatics: Linking the Molecular World to the Clinical World.
    Clin Pharmacol Ther. 2012 May 2. PubMed abstract

  • Ouzounis CA.
    Rise and demise of bioinformatics? Promise and progress.
    PLoS Comput Biol. 2012 Apr;8(4):e1002487. PubMed abstract

  • Sharma V, Sarkar IN.
    Bioinformatics opportunities for identification and study of medicinal plants.
    Brief Bioinform. 2012 May 15. PubMed abstract

  • Scholz SW, Mhyre T, Ressom H, Shah S, Federoff HJ.
    Genomics and bioinformatics of Parkinson's disease.
    Cold Spring Harb Perspect Med. 2012 Jul;2(7):a009449. PubMed abstract

  • Hartler J, Tharakan R, Köfeler HC, Graham DR, Thallinger GG.
    Bioinformatics tools and challenges in structural analysis of lipidomics MS/MS data.
    Brief Bioinform. 2012 Jul 3. PubMed abstract

  • Manconi A, Vargiu E, Armano G, Milanesi L.
    Literature Retrieval and Mining in Bioinformatics: State of the Art and Challenges.
    Adv Bioinformatics. 2012;2012:573846. PubMed abstract

  • Valencia A, Hidalgo M.
    Getting personalized cancer genome analysis into the clinic: the challenges in bioinformatics.
    Genome Med. 2012 Jul 30;13(7):61. PubMed abstract

  • Logares R, Haverkamp TH, Kumar S, Lanzén A, Nederbragt AJ, Quince C, Kauserud H.
    Environmental microbiology through the lens of high-throughput DNA sequencing: Synopsis of current platforms and bioinformatics approaches.
    J Microbiol Methods. 2012 Jul 28. PubMed abstract

  • Furnham N, de Beer TA, Thornton JM.
    Current challenges in genome annotation through structural biology and bioinformatics.
    Curr Opin Struct Biol. 2012 Aug 9. PubMed abstract

  • Palma JP, Benitz WE, Tarczy-Hornoch P, Butte AJ, Longhurst CA.
    Neonatal Informatics: Transforming Neonatal Care Through Translational Bioinformatics.
    Neoreviews. 2012 May 1;13(5):e281-e284. PubMed abstract

  • Yan Q.
    Translational bioinformatics in psychoneuroimmunology: methods and applications.
    Methods Mol Biol. 2012;934:383-400. PubMed abstract

  • Fuellen G, Dengjel J, Hoeflich A, Hoeijmakers J, Kestler HA, Kowald A, Priebe S, Rebholz-Schuhmann D, Schmeck B, Schmítz U, Stolzing A, Sühnel J, Wuttke D, Vera J.
    Systems Biology and Bioinformatics in Aging Research: A Workshop Report.
    Rejuvenation Res. 2012 Sep 5. PubMed abstract

  • Malkaram SA, Hassan YI, Zempleni J.
    Online tools for bioinformatics analyses in nutrition sciences.
    Adv Nutr. 2012 Sep 1;3(5):654-65. PubMed abstract

  • Charoentong P, Angelova M, Efremova M, Gallasch R, Hackl H, Galon J, Trajanoski Z.
    Bioinformatics for cancer immunology and immunotherapy.
    Cancer Immunol Immunother. 2012 Sep 18. PubMed abstract

  • Bernt M, Braband A, Middendorf M, Misof B, Rota-Stabelli O, Stadler PF.
    Bioinformatics Methods for the Comparative Analysis of Metazoan Mitochondrial Genome Sequences.
    Mol Phylogenet Evol. 2012 Sep 27. pii: S1055-7903(12)00376-4. PubMed abstract

  • Mohabatkar H, Keyhanfar M, Behbahani M.
    Protein Bioinformatics Applied to Virology.
    Curr Protein Pept Sci. 2012 Oct 9. PubMed abstract

  • Fedorova ND, Moktali V, Medema MH.
    Bioinformatics approaches and software for detection of secondary metabolic gene clusters.
    Methods Mol Biol. 2012;944:23-45. PubMed abstract

  • Bellazzi R, Masseroli M, Murphy S, Shabo A, Romano P.
    Clinical Bioinformatics: challenges and opportunities.
    BMC Bioinformatics. 2012;13 Suppl 14:S1. PubMed abstract

  • Primig M.
    The bioinformatics tool box for reproductive biology.
    Biochim Biophys Acta. 2012 Dec;1822(12):1880-95. PubMed abstract

  • Fang X, Bai C, Wang X.
    Bioinformatics insights into acute lung injury/acute respiratory distress syndrome.
    Clin Transl Med. 2012 Jun 9;1(1):9. PubMed abstract

  • Mulas F, Sacchi L, Zagar L, Garagna S, Zuccotti M, Zupan B, Bellazzi R.
    Knowledge-based bioinformatics for the study of mammalian oocytes.
    Int J Dev Biol. 2012;56(10-11-12):859-866. PubMed abstract


Links and references provided by Lynda Ellis