| 7th ASSIG - Special Interest Group meeting on Alternative Splicing | |
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United States - MA - Boston |
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| Hosted by: | Satellite conference prior to ISMB |
| Venue: | John B. Hynes Memorial Convention Center |
| Dates: | Jul 08, 2010 through Jul 09, 2010 |
| Call for Proceedings Presentations: | 2010-03-01 through 2010-05-31 |
| Call for Posters: | 2010-03-01 through 2010-05-31 |
| Event Registration: | 2010-03-01 through 2010-07-08 |
| Early Registration Deadline: | 2010-05-28 |
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Description |
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| About the Workshop The organizers of AS-SIG would like to invite you to participate in the 7th Special Interest Group meeting on Alternative Splicing (AS-SIG), on July 9-10, 2010 in Boston, MA. The meeting is running under the title "Emerging connections between chromatin, non-coding RNA and splicing" and is scheduled immediately before ISMB’10. AS-SIG’10 follows on from initial and subsequent successful Alternative Splicing SIG meetings held at the Pacific Symposium of Biocomputing 2004, and the ISMB in 2005 - 2009. Background and Aims Alternative splicing is highly regulated, as it can occur specifically in different cell or tissue types, and is linked to many cellular processes such as cell differentiation, sex-determination and apoptosis. Importantly, defects in either cis-acting regulatory elements or trans-acting factors can lead to aberrant splicing and lead to human disease. Recent advances in sequencing technologies have provided the opportunity to obtain genome wide information on the regulation of RNA splicing by specific factors and in various conditions. Additionally, recent analyses have shown a relation between the chromatin structure of the DNA and the regulation of RNA in transcription and splicing. There is now plenty of evidence that the configuration of the chromatin influences the regulation of alternative splicing, by affecting the elongation rate of the RNA polymerase II (PolII) or by helping or hindering the recruitment of specific splicing-factors. Consistent with these evidences, computational analyses have also indicated that the actual positioning of nucleosomes may be key in the recognition of the exon-intron structures in the pre-mRNA. In parallel with these advances, recent genome-wide studies have shown that the human genome is pervasively transcribed and is capable of producing many small RNAs (sRNAs). These sRNAs, which include micro-RNAs (miRNAs), small interfering RNAs (siRNAs), PIWI-interacting RNAs (piRNAs), do not encode for protein and have potentially multiple regulatory roles. They can regulate genes and genomes at different levels, including chromatin structure, transcription, RNA processing, RNA stability and translation. The biogenesis of some of the sRNAs is well established, like for miRNAs, but it is less clear in other cases. For instance, some of these small RNAs have been associated to the promoter regions of genes and are independent of the miRNA processing machinery. These new regulatory mechanisms provide a new view on the regulation of RNA expression. During the last few years, a connection between small RNAs, chromatin configuration and splicing has emerged. Some of the sRNAs can target internal gene regions and induce chromatin marks that affect the rate of transcriptional elongation, therefore affecting the splicing of pre-mRNAs. This three-way crossing between the structure of chromatin, the activity of small RNAs and the post-transcriptional regulation of RNA, in particular, splicing, opens up a new view of the regulation of gene expression. In this meeting we aim to provide an opportunity to bring world experts in these three fields to discuss in common the recent advances and put forward new ideas. Moreover, as these studies require a very strong computational analysis of genome-wide high-throughput, we expect that the context of the ISMB conference, and the participation of computational experts, will give rise to a fruitful interaction and a excellent basis for building a community of shared resources and tools in this new raising field. Abstract submission AS-SIG features a keynote, invited talks, as well as short talks and posters selected from submitted abstracts, based on scientific quality and novelty. Talk and poster abstracts will be published in the SIG handout. Abstracts are invited in, but not limited to, the following topics: - Genome-wide analysis of chromatin signatures - Histone modifications in gene regulation and alternative splicing - Coupling between transcription and pre-mRNA splicing - Role of non-coding RNAs in gene regulation and splicing - Genome-wide characterization of small RNAs - The role of small RNAs in Histone modifications - The role of chromatin in splicing regulation in disease and cancer We encourage all speakers to bring posters to the poster session. |
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| Additional Information | |
| Event URL: | http://www.alternative-splicing.org/as-sig-10/ |
| ISCB Member Discount: | None |
| Contact Person: | Eduardo Eyras ([javascript protected email address]) |
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