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In this issue:

Featured Jobs:

  • Research Fellow - Biology

  • Postdoc in Computational Genomics

  • Faculty Member - Computational Biology, Machine Learning, & Digital Health

  • Postdoctoral Associate

  • Faculty Assistant Professor in Artificial Intelligence for Animal Improvement

Article: Reference Letters: Who to Ask, How to Ask, and How to Help

Closing Soon on the ISCB Career Center

Career Compass Featured Jobs

Research Fellow - Biology
The Infinity Fellowship
Job description:
We are a frontier artificial-intelligence laboratory, still in stealth, established for a single purpose: to build an AI capable of original discovery — a system that does not merely retrieve and recombine what is already known, but reasons toward genuinely new understanding of the problems put to it. We hold that an instrument able to truly discover is among the most consequential technologies humanity will ever build, and we are building it.

Our system has already produced results beyond the reach of any human team. We have demonstrated its power on a small number of problems. The purpose of this fellowship is to establish how far that power extends.

This is an invitation to bring a small number of researchers who will form the inaugural cohort of the Infinity Fellowship who will spend a year aiming this instrument at the hardest unsolved problems in their fields.

You choose the problems — the ones shelved because they demanded a decade. You carry each from formulation to validated result. You publish as lead author.

The terms are plain: a full-time salaried appointment of roughly one year ($125,000), hybrid in the San Francisco East Bay, with relocation support and visa sponsorship for international Fellows. It pays like a strong postdoc. No background in AI is required; we weigh the ability to learn above experience with any method. Top-performing Fellows will be offered permanent research positions.

The application takes ten minutes to begin: your CV, and a few sentences on the problem you would start with. The full one-page proposal — why it has resisted solution, what its solution would make possible — can follow.

pfa.zto77.com/apply-biology-life-sciences

Proposals received by Sep 15 will be considered first for the inaugural cohort, which convenes in September. Every application receives an answer within a week.

Few are present, in any era, at the founding of a new instrument of discovery. Bring the problem worth your year.

Postdoc in Computational Genomics at Harvard School of Public Health
Harvard University
Environmental Health, Biostatistics
Cambridge, Massachusetts, USA
Job description: The Broad Institute of MIT & Harvard is seeking a highly motivated computational Postdoctoral Associate to join the Haber Lab and Klarman Cell Observatory to discover the complex cellular processes and structures that underlie our airways ability to defend themselves from the wide range of threats in the air around us.

Our interdisciplinary research group uses machine learning and genomics to study the immunology of environmental health and particularly physiological mechanisms of lung inflammation and asthma. We use cutting edge genomics and computational methods to answer major questions in the field: how do the airways of the lungs detect danger signals, such as allergens, viruses, or toxins, and trigger an immune response? Which are the most important types of ‘sentinel cells’ that are on the lookout for danger in inhaled air, and able to co-ordinate an effective defense? Prospective applicants should have made significant contributions to their area of study, as evidenced by a strong publication record. We are seeking creative and highly motivated individuals who want to work in a dynamic, multi-disciplinary research environment.

Qualifications

  • PhD or equivalent in computational biology, machine learning, data science, artificial intelligence, computer science, statistics, mathematics, or another quantitative field.

  • Candidates holding a degree in biological or medical science are also welcome to apply if they have strong background in computational or statistical work.

  • Strong interpersonal and communication skills, experience presenting and communicating research.

  • Excellent problem solving and quantitative analysis skills

Faculty Member - Computational Biology, Machine Learning, & Digital Health
Institute for Systems Biology
Seattle, Washington, USA
Job description: The Institute for Systems Biology (ISB) seeks a highly motivated and

talented Assistant, Associate, or Full Professor to join our faculty and lead transformative efforts in AI, machine learning, and computational biology to bridge the gap between basic science and next-generation medicine. The successful candidate will have a strong background in computational biology, statistics, machine learning/AI or a related field, and a passion for applying these techniques to address complex biological or medical problems.

Biomedical research pioneer Dr. Leroy Hood founded ISB in 2000 as the first-of-its-kind institute dedicated to systems biology. Unlike traditional academic departments, our faculty are cross-disciplinary, which enables us to take on big, complex problems. ISB is deeply committed to sharing our knowledge with society: we participate in the formation of companies, and strategically collaborate with healthcare systems and industry to improve human health and accelerate science.

ISB’s computational capabilities are in biological modeling and simulation, machine learning, biostatistical methods, bioinformatics, medical informatics, applied to: genomics, phenomics and exposomics. ISB's technical capacities include genomics, transcriptomics, metagenomics, proteomics, metabolomics, imaging, and single-cell omics. Accordingly, ISB faculty develop novel measurement technologies, formal theories and computational tools to support all aspects of systems biology and systems medicine, and these unique resources are shared across the institute. ISB’s affiliation with Providence, one of the largest not-for-profit health care systems in the United States, gives ISB access to unique resources including clinical trials, patient samples, 30 million electronic health records (EHRs), imaging, and the ability to translate discoveries into clinical applications that benefit patients.

Responsibilities:

  • Establish and maintain a research program in applied mathematics, statistics, computer science or data science to investigate fundamental biological processes and their relevance to human health.

  • Pioneer innovative computational frameworks to integrate multimodal biological and clinical data, such as genomics, proteomics, phenomics, or specialized domains, such as deep immunophenotyping, imaging, health dynamics, and spatiotemporalomics data that can drive new scientific paradigms or personalized medicine with actionable insights for patient care.

  • Develop and apply innovative methods to integrate data-driven and knowledge-based approaches for discovery of mechanisms and clinical decision support.

  • Collaborate with other researchers within the institute, external partners to translate computational discoveries into real-world applications in health care, from prevention to detection to treatment of diseases.

  • Secure external funding to support research activities and expand the scope of the research program.

  • Mentor graduate students, postdoctoral fellows, and undergraduate students.

  • Contribute to ISB's research and educational mission.

Expected Salary: Compensation for this role will be based on skills, experience, and rank upon hire in the expected range of $155,000 to $300,000 per year.

Postdoctoral Associate
Yale University
Department of Biostatistics
New Haven, Connecticut, USA
Job description: Leying Guan is an Associate Professor of Biostatistics at Yale Univ. Her team develops statistical and machine-learning methods for reliable scientific discovery from complex, high-dimensional data, along three interconnected directions: (1) models that capture structure in heterogeneous, high-dimensional data — latent-factor and multi-view models, structured/tensor estimation, high-dimensional regression, and integrative modeling; (2) inference that stays valid after complex or data-adaptive analysis — conformal prediction, robust inference, adaptive signal detection with error-rate control, and post-selection assessment; and (3) computational biology — building tools with improved statistical rigor for large-scale immune, single-cell, and multi-omics data, in collaboration with immunologists and consortium-scale data resources. Looking ahead, she is currently extending all three directions further toward new model structures and data types.

Depending on background and interest, projects may span new computational models for single-cell data targeting unresolved challenges; software and computational platform development with large-scale application to consortium data resources; theoretical and methodological development in robust uncertainty quantification or high-dimensional structured modeling. Candidates also have good flexibility to propose and develop their own research topics.

You don't need to fit all of these, but should be strong on at least one axis:

Methodologists: rigorous training in statistics, biostatistics, ML theory, comfortable enough with code and real data to implement and validate methods at scale.

Computational biologists / strong engineers moving into methodology: excellent software and data engineering skills (scalable computing, single-cell or genomic data pipelines).

ML-trained researchers curious about biology: strong deep learning background who are interested in working on problems with real statistical stakes in a biological domain and are motivated to learn the biology as they go.

Across all profiles, what matters most: genuine intellectual motivation, comfort working hands-on with real and large-scale data, and interest in building methods that are both theoretically sound and practically useful.

Compensation

Salary: Compensation will follow Yale University’s postdoctoral compensation guidelines and will be commensurate with experience.

Preferred Start Date: Preferred Early 2027, but negotiable. Applications will be considered until the position is filled.

International applicants are welcome.

Qualifications

PhD (or near completion) in Statistics, Computer Science, Biostatistics, Computational Biology, or a related quantitative field, with a track record in either rigorous methodology, computational software development, or applying/extending computational methods to real, large-scale single cell/omics data.

Assistant Professor in Artificial Intelligence for Animal Improvement
Purdue University, Department of Animal Sciences
Indianapolis, Indiana, USA
Job description: Develop the next generation of data analytics and AI-enabled methods for selecting animals, deriving novel phenotypes, and implementing precision management or interventions to improve animal production systems.

Position

Purdue University invites applications for a tenure-track assistant professor position focused on data analytics and artificial intelligence (AI)-enabled selection in animal systems. This position will be housed in Indianapolis where the candidate will have the opportunity to shape the academic and research programs offered there. We seek an innovative scholar who develops and applies AI, machine learning, data science, genomics, biotechnology, and predictive modeling to improve decision-making across animal agriculture. The successful candidate will use advanced data science and AI-enabled techniques in areas of interest, including selection and breeding of animals, derivation of novel traits and high-throughput phenotypes, health interventions, infectious disease control, precision management strategies, or production systems. The ultimate goal is to help create the next generation of intelligent animal agriculture. Candidates developing foundational or applied methods in AI, computational biology, quantitative genetics, engineering, bioinformatics, multi-omics data analytics, statistics, or related fields whose work can accelerate improvement across livestock, poultry, aquaculture, companion animals, biomedical animal models, and other relevant animal systems are encouraged to apply. Prior research centered on agricultural animals is valued but not required when a candidate's expertise can be applied to consequential problems in animal agriculture and health.

The successful candidate will establish an internationally recognized and externally funded research program; collaborate across disciplines; mentor graduate students and postdoctoral scholars; and contribute to undergraduate and graduate education. The anticipated appointment will be in the Department of Animal Sciences with opportunities for collaboration and appropriate joint or courtesy appointments across Purdue.

Grand Challenge

How can advanced data analytics and AI enable faster, more accurate, and responsible genetic improvement and precision management to enhance animal health, resilience, productivity, welfare, and sustainability?

Potential Areas of Scholarship

  • AI-enabled selection, breeding, and genetic improvement, including genomic prediction of breeding values and phenotypes and next-generation quantitative genetics

  • Machine learning and foundation models that integrate genomic, phenotypic, environmental, management, imaging, sensor, and multi-omics data

  • High-throughput and digital phenotyping using computer vision, acoustic monitoring, wearable and spectroscopic technologies, robotics, and advanced sensing/diagnostics

  • Selection of animals and derivation of novel traits for animal health and welfare, disease resistance, climate resilience, reproduction, efficiency, and product quality

  • AI-guided selection of nutritional, microbiome, therapeutic, or management interventions

  • Digital twins, causal models, and decision systems that predict animal performance across environments and production systems

  • Responsible and transparent AI, including model validation, interpretability, uncertainty, fairness, data governance, and deployment in real-world animal systems

  • Large-scale and complex data integration from diverse livestock data sources

  • Precision animal agriculture, autonomous monitoring, and producer-facing decision support

  • One Health applications connecting animal, human, food, and environmental health

Responsibilities

  • Develop a high-impact, externally funded research program in AI-enabled selection for farm animal systems.

  • Publish foundational and translational scholarship in impactful venues in the field and develop data resources, algorithms, software, intellectual property, computing infrastructure, or deployable technologies as appropriate.

  • Build interdisciplinary collaborations across agriculture, engineering, computing, veterinary medicine, life sciences, statistics, health, and livestock industries.

  • Teach courses aligned with the candidate's expertise and contribute to curricula in AI, data science, genomics, biotechnology, quantitative methods, or animal systems. Course modality is in person. The potential may exist for teaching online/distance courses during the academic year.

  • Mentor undergraduate students, graduate students, visiting scholars, and postdoctoral researchers.

  • Contribute service and engagement consistent with Purdue's land-grant mission.

Reference Letters:
Who to Ask, How to Ask, and How to Help

Reference letters are a standard part of applying for positions, programs, or funding. They’re also one of the pieces of applications that many people leave until the last minute. Thinking about reference letters early, being prepared, and making the process as easy as possible for referees is more likely to result in a strong letter that meaningfully supports your application.

Who to Ask

Remember that a reference letter is only as strong as the person’s ability to speak to your work, your character, and your potential. A glowing but generic letter from someone who barely knows you will rarely serve you as well as a specific, enthusiastic one from someone who has worked closely with you.

Aim for references who can speak directly to different facets of your work and experience, rather than people to whom you only have a fleeting connection and who would all say essentially the same thing. Think about who you’ve worked with or learned from. A supervisor or PI, a dissertation committee member, or a professor who knows your academic work can all be great options.

How to Ask

Even if you’re absolutely certain that the answer will be yes, reference letter etiquette dictates that you always ask someone, officially, to act as a reference for you. And when you do ask, do it early. Faculty and supervisors are busy, and a reference request made the week it’s due is not only unprofessional, but it puts them in a time crunch and rarely results in a strong letter, if one is able to be written at all.

When you reach out, be direct about what you’re asking for, providing as much context and detail from the outset as you can. A message that says “I’m applying for a postdoctoral position in computational genomics and I’d love to include you as a reference because of the work we did together on X” is far more compelling than a vague “would you be willing to write me a reference letter?”

Finally, remember that just because you ask them to write a reference letter doesn’t mean your potential referee will say yes. Make it clear that you understand they might not be able to help. Something simple like “please let me know if you don’t feel you’re in a position to write a strong letter” signals that you respect their time and their honesty.

Setting Them Up for Success

The easier you make the process for your referee, the stronger the letter is likely to be. Once someone agrees to write you a reference letter, at minimum, you should send:

  • Your current CV

  • A clear description of the position or program you’re applying for

  • Any specific qualities or experiences you’d like them to highlight

  • The submission deadline

If you worked on a project together that’s relevant to the application, a brief reminder of that work can be helpful too. Referees are often writing multiple letters for multiple people, and a quick note jogging their memory about a particular project or accomplishment gives them concrete material to draw from.

Finally, always follow up with a thank you once the letter has been submitted and again when you hear back about the outcome, whatever it may be. It’s a small gesture that goes a long way.

Final Thoughts

A strong reference letter is built before you send the request. It’s the product of relationships you’ve invested in, work you’ve shown up for, and the care you take in how you ask. Approach the process thoughtfully and your references will be able to advocate for you in the ways that matter most!

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