| Poster Z01 |
| Estimating genomic diversity of the cleavage site peptides among H5HA avian influenza ameliorates the synthesis of influenza vaccine |
| Sherry Dadgar- Rochester Institute of Technology |
| Sherry Dadgar (Rochester Institute of Technology, Bioinformatics); Michael Osier (Rochester Institute of Technology, Bioinformatics); Carol Marchetti (Rochester Institute of Technology, Statistics and Mathematics); Gary R. Skuse (Rochester Institute of Technology, Bioinformatics); |
| Short Abstract: We employed, in silico analysis of hemagglutinin to predict cleavage sites of strains employing SigCleave and SignalP 3.0. Then we employed information theory methods, mutual information and Pearson Chi-squared tests to identify possible phenotypic and genotypic characteristics between pathogenic and low/non-pathogenic HAH5 cleavage site in USA and improve vaccine development. |
| Long Abstract: Click Here |
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| Poster Z03 |
| BioCatalogue: A Curated Web Service Registry for Life Science Community |
| Franck Tanoh- University of Manchester |
| Khalid Belhajjame (University of Manchester, School of computer science); Carole Goble (University of Manchester , School of Computer science); Jiten Bhagat (University of Manchester , School of Computer science); Katy Wolstencroft (University of Mancheste, School of Computer science); Robert Stevens (University of Manchester, School of Computer science); Rodrigo Lopez (EMBL European Bioinformatics Institute, EBI); Eric Nzuobontane (EMBL European Bioinformatics Institute, EBI); Thomas Laurent (EMBL European Bioinformatics Institute, EBI); Steve Pettifer (University of Manchester, School of Computer science); |
| Short Abstract: BioCatalogue provides a central registry of curated biological Web Services. A place where providers, users and curators can register, annotate and search for Web Services. BioCatalogue is a place where the community can meet the maintainers of these services. It is co-developed by the University of Manchester and the EMBL-EBI. |
| Long Abstract: Click Here |
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| Poster Z04 |
| Real-Time Volume Ray Tracing For Bioinformatics Applications |
| Lukas Marsalek- Saarland University |
| Anna Dehof (Saarland University, Chair for Bioinformatics); Philipp Slusallek (DFKI Saarbruecken & Saarland University, Agents and Simulated Reality); Andreas Hildebrandt (Saarland University, Center for Bioinformatics); |
| Short Abstract: An important data source in structural bioinformatics are scalar three-dimensional data sets. The method of choice for visualizing such data sets is volume ray tracing, a technique traditionally associated with high computational demands. In this work, we present an interactive real-time volume ray tracer for use in the bioinformatics field. |
| Long Abstract: Click Here |
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| Poster Z08 |
| A model structure of the human potassium channel Kv7.2 in complex with a potent selective opener |
| Yana Gofman- Tel-Aviv University |
| Asher Peretz (Tel-Aviv University, Department of Physiology & Pharmacology); Liat Pell (Tel-Aviv University, Department of Physiology & Pharmacology); Yoni Haitin (Tel-Aviv University, Department of Physiology & Pharmacology); Bernard Attali (Tel-Aviv University, Department of Physiology & Pharmacology); Nir Ben Tal (Tel-Aviv University, Biochemistry); |
| Short Abstract: We generated a model-structure of the Kv7.2 human voltage-gated potassium channel in complex with NH29, a compound stabilizing the open state. This potent and selective opener binds to the voltage sensing domain in the interface formed between three helices. The model guided the design of mutagenesis experiments. |
| Long Abstract: Click Here |
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| Poster Z10 |
| The Bioinformatics Resource Manager & Gaggle: a platform for management, integration and analysis of systems biology data |
| Mudita Singhal- PNNL |
| Anuj Shah (PNNL, Scientific Data Management); Tara Gibson (PNNL, Scientific Data Management); Ian Gorton (PNNL, Applied Computer Science); Benson Kalahar (PNNL, Global Security Tech & Policy); Katrina Waters (PNNL, Computational Biol & Bioinfor); Dan Tenenbaum (ISB, Baliga Group); Christopher Bare (ISB, Baliga Group); Nitin Baliga (ISB, Baliga Group); |
| Short Abstract: This poster demonstrates the capabilities of the Bioinformatics Resource Manager (BRM, a general purpose data management and integration software that provides the user with data storage, annotation, and merging capabilities and utilizes the Gaggle communication model to broadcast data to the integrated application tools, such as Cytoscape and the Multi-Experiment Viewer. |
| Long Abstract: Click Here |
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| Poster Z15 |
| Computational Methods for Dissection of MicroRNA Function |
| Igor Ulitsky- Tel Aviv University |
| Louise Laurent (The Scripps Research Institute, Center for Regenerative Medicine); Franz-Josef Müller (The Scripps Research Institute, Center for Regenerative Medicine); Jeanne F. Loring (The Scripps Research Institute, Center for Regenerative Medicine); Ron Shamir (Tel Aviv University, Blavatnik School of Computer Science); |
| Short Abstract: We present two methods for improving discovery of miRNA function and their targets. The first detects enrichment of miRNA targets in sets of co-annotated or co-expressed genes. The second detects groups of miRNAs that jointly target a cellular pathway, utilizing information on protein interactions, putative miRNA targets and miRNA expression. |
| Long Abstract: Click Here |
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| Poster Z17 |
| The Prediction of Protein-Protein Interaction Networks in Rice Blast Fungus |
| FEI HE- CHINA AGRICULTRUAL UNIVERSITY |
| YAN ZHANG (China Agricultural University, State Key Laboratory for ArgoBiotechnology); YONG-ZI CHEN (China Agricultural University, State Key Laboratory for ArgoBiotechnology); ZIDING ZHANG (China Agricultural University, State Key Laboratory for ArgoBiotechnology); YOU-LIANG PENG (China Agricultural University, State Key Laboratory for ArgoBiotechnology); |
| Short Abstract: Large-scale PPI mapping projects have not been implemented for Magnaporthe grisea, which causes the most severe rice disease. We have predicted protein interaction network of the pathogen. This will provide new insights into the functional genomics of this fungus. |
| Long Abstract: Click Here |
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| Poster Z19 |
| Promoting coherent minimum reporting guidelines for biological and biomedical investigations: the MIBBI project |
| Chris Taylor- EMBL-EBI |
| Susanna-Assunta Sansone (EMBL-EBI, Microarray Group); Philippe Rocca-Serra (EMBL-EBI, Microarray Group); Dawn Field (Oxford Centre for Ecology and Hydrology, Molecular Evolution and Bioinformatics Group); |
| Short Abstract: Minimum information (MI) checklists specify the content to provide when reporting research; ontology-aware tools such as 'ISAcreator' (http://isatab.sourceforge.net/isacreator.html) help researchers create semantically rich checklist-compliant reports. MIBBI provides access to MI checklists, their developers and appropriate tools, and is driving the development of a new, modular, fully integrated checklist suite (http://mibbi.org/). |
| Long Abstract: Click Here |
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| Poster Z22 |
| Serum Paraoxonase's Structure and Its Interaction with VX |
| Matthew Peterson- The MITRE Corporation |
| Steven Fairchild (The MITRE Corporation, Emerging Technologies Office); Wenling Chang (The MITRE Corporation, Emerging Technologies Office); Chang-Guo Zhan (University of Kentucky College of Pharmacy, Department of Pharmaceutical Science); Adel Hamza (University of Kentucky College of Pharmacy, Depertment of Pharmaceutical Science); Douglas Cerasoli (US Army Medical Research Institute of Chemical Defense, Physiology and Immunology Branch); |
| Short Abstract: Human serum paraoxonase (HuPON1) is a potential bioscavenger for organophosphorus nerve agents such as VX. HuPON1's 3D structure and interaction mechanism with VX are unknown. This study computationally characterized HuPON1's 3D structure, and its binding mechanism for VX. Key active site residues and associated functions were determined from the results. |
| Long Abstract: Click Here |
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