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UPCOMING DEADLINES & NOTICES

  • Virtual platform uploads open
    ISMB/ECCB 2025
    June 17, 2025
  • ISCB Offices Closed
    June 19, 2025
  • Deadline for Early Bird Registration
    INCOB 2025
    June 21, 2025
  • Final tutorial materials due for posting (You have until 23:59 Anywhere on Earth)
    ISMB/ECCB 2025
    June 25, 2025
  • Abstract acceptance notification
    INCOB 2025
    July 1, 2025
  • Deadline for submissions of final versions
    INCOB 2025
    July 1, 2025
  • Travel grant award notification
    INCOB 2025
    July 8, 2025
  • Last day to upload ANY/ALL files to the virtual platform (You have until 23:59 Anywhere on Earth) *no extensions*
    ISMB/ECCB 2025
    July 11, 2025
  • Deadline for early bird registration
    INCOB 2025
    July 21, 2025

Upcoming Conferences

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Oral Presentations Schedule


Programme Schedule tentative and subject to change. 
Programming time is Eastern Standard Time.


RSG Schedule

Monday – Day 1 – November 16, 2019
Go directly to: Tuesday, Nov 17Wednesday, Nov 18 (DREAM)Thursday, Nov 19 (DREAM)
START
TIME
END
TIME
SESSION
TYPE
10:00 am 10:05 am Welcome and Intro
10:05 am 10:50 am Keynote - Su-In Lee
Explainable Artificial Intelligence for Biology and Health
10:50 am 11:50 am Complex Molecular Interactions
  • Mapping cell structure across scales by fusing protein images and interactions - Yue Qin
  • A Network-based comparative framework to study conservation and divergence of proteomes in plant phylogenies - Junha Shin
  • Mapping gene regulatory networks in the Drosophila brain using single-cell transcriptomics and epigenomics - Sara Aibar
  • Identifying diverse modes of TF-DNA interactions in ChIP-exo data - Anushua Biswas
11:50 am 12:30 pm Break
12:30 pm 1:15 pm Special Session Keynote - Sara Mostafavi
Machine Learning for extracting meaningful patterns in large genomics datasets
1:15 pm 2:15 pm Special Session on Regulatory and Systems Genomics in Immunology
  • Integrated multi-omics approach to identifying regulatory mechanisms in cancer metastatic processes - Saba Ghaffari
  • Varmole: A biologically drop-connect deep neural network model for prioritizing disease risk variants and genes - Nam Nguyen
  • Inferring cellular trajectories from scRNA-seq in pseudospace - Aly Khan
  • Inferring the pan-cancer interactions and prognostic significance of driver mutations and the tumor immune microenvironment - Masroor Bayati
2:15 pm 3:00 pm Special Session Keynote - Harinder Singh
Genomic Regulatory Codes and Transcriptional Circuits Controlling Mammalian Cell States and their Dynamics
3:00 pm 4:00 pm Posters
Tuesday – Day 2 – November 17, 2019
Go directly to: Monday, Nov 16Wednesday, Nov 18 (DREAM)Thursday, Nov 19 (DREAM)
START
TIME
END
TIME
SESSION
TYPE
    Open Poster Viewing
10:00 am 10:05 am Welcome and Intro
10:05 am 10:50 am Keynote - Brenda Andrews
Systematic genetic perturbation screens to map biological networks
10:50 am 11:50 am Single Cell Analysis
  • SPICEMIX: Integrative single-cell spatial modeling for inferring cell identity - Benjamin Chidester
  • Chromatin accessibility and transcription factor activity estimation on single cells - Ivan G. Costa
  • Mapping vector field of single cells - Yan Zhang
  • Developmental trajectory of pre-hematopoietic stem cell formation from endothelium - Qin Zhu
11:50 am 12:30 pm Break
12:30 pm 1:15 pm Keynote - Ziv Bar-Joseph
Reconstructing dynamic regulatory networks from time series single cell data
1:15 pm 2:15 pm From Sequence to Function
  • Ledidi: Designing genome edits that induce functional activity - Jacob Schreiber
  • Genome-wide identification and analysis of RNA structural disruptions induced by single nucleotide variants - Zhengqing Ouyang
  • Neural Networks Can Extract Thermodynamic DNA Sequence Affinities from Genomic Occupancy Profiles of Transcription Factor Binding - Amr Alexandari
  • Assessing the enrichment of somatic mutations in TF binding sites - Harshit Sahay
2:15 pm 3:00 pm Keynote - Elaine Mardis
Pediatric CNS Cancers:  Exploring Clinical Data to Inform Treatment
3:00 pm 4:00 pm Networking


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DREAM Schedule

Wednesday - Day 3 – November 18, 2020
Go directly to: Monday, Nov 16Tuesday, Nov 17Thursday, Nov 19 (DREAM)
START
TIME
END
TIME
SESSION
TYPE
10:00 am 10:10 am Welcome and Introductory Remarks from Pablo Meyer
10:10 am 10:50 am Keynote - Rada Mihalcea
Language as a Window into Human Behavior: A Computational Perspective
10:50 am 11:40 am Preterm Birth Prediction: Transcriptomics DREAM Challenge
Session Chair
- James Costello
  • Crowdsourcing assessment of maternal blood multi-omics for predicting gestational age and preterm birth - Adi Tarca 
  • Dealing with high dimensional data to predict preterm birth - Balint A. Pataki and Istvan Csabai (Team ELTEcomplex) 
  • Omics-based prediction of preterm birth by Gaussian Process Regression models - Yuanfang Guan (Team gyuanfan)
  • SVM-based approach to predict preterm birth using omics data - Rintu Kutum (Team rABiT)
11:40 am 12:10 pm Metadata Automation DREAM challenge
Session Chair
- Thomas Schaffer
  • Metadata Automation DREAM Challenge - Denise Warzel
  • Biomedical Analysis of Composite Ontological Networks - Lauren Cirillo (Team ENGR Dynamics)
  • An Iterative Strategy Optimizing CDE Recommendations from Real-World Data - Attila L. Egyedi (Team CEDAR Team)
  • Metadata Automation: A TF-IDF and Nearest Neighbors Approach - Emily Hartley (Team )
12:10 pm 12:40 pm Lunch Break
12:40 pm 1:30 pm CTD2 Pancancer Drug Activity DREAM Challenge
Session Chair
- Robert Allaway
  • CTD2 Pancancer Drug Activity DREAM Challenge - Robert Allaway & Eugene Douglass
  • Predicting drug targets by integration of drug sensitivity data and drug gene signature data - the NETPHAR strategy - Wenyu Wang (Team netphar)
  • A multitask neural network approach for predicting drug targets from chemogenomics data - Fangping Wang (Team Atom)
1:30 pm 1:40 pm Break
1:40 pm 2:30 pm RA2 DREAM Challenge: Automated Scoring of Radiographic Joint Damage
Session Chair - Jim Costello
  • Introduction to the RA2 DREAM Challenge: Automated Scoring of Radiographic Joint Damage - Lou Bridges
  • Scoring and benchmarking for the RA2 DREAM Challenge - Jake Chen
  • Prediction of Rheumatoid Arthritis Scores Ariel's Method (PRASAM) - Ariel Israel
  • A multistage deep learning method for scoring radiographic hand and foot joint damage in rheumatoid arthritis - Isaac Dimitrovsky
  • Li and Guan RA2 DREAM Challenge Solution - Hongyang Li
  • Team Csabaibio RA2 DREAM Challenge Solution - Alex Olar
2:30 pm 3:30 pm Posters
Thursday - Day 4 – November 19, 2020
Go directly to: Monday, Nov 16Tuesday, Nov 17Wednesday, Nov 18 (DREAM)
START
TIME
END
TIME
SESSION
TYPE
10:00 am 10:10 am Welcome and Introductory Remarks
Pablo Meyer
10:10 am 10:50 am Keynote - Dina Machuve
Poultry Diseases Diagnostics using Deep Learning
10:50 am 11:40 am CTD2 Beat AML DREAM Challenge
Session Chair
- Brian White
  • CTD2 Beat AML DREAM Challenge: Strategies for Prediction of Drug Efficacy and Patient Outcomes - Jeff Tyner
  • Prediction of drug sensitivity using a multi-response model - Rasmus Froberg Brøndum
  • Beat AML SC2: Predicting clinical response using feature selection for survival analysis - Yasin Memari
11:40 am 12:25 pm BEAT-PD DREAM Challenge
Session Chair
- Solveig Sieberts
  • Parkinson's disease symptom assessment in free-living conditions; the BEAT-PD Challenge - Solveig Sieberts
  • Personalized prediction of on-off medication state from wearable-derived time-series features - Yidi Huang
  • Assessment of Parkinson's disease dyskinesia in a free-living environment - Alex Page
  • Tremor severity in Parkinson’s disease can be monitored in a free-living environment - Yuanfang Guan
12:25 pm 12:55 pm Lunch Break
12:55 pm 1:30 pm The EHR Challenges (The COVID-19 EHR DREAM Challenge and the EHR DREAM Challenge)
Session Chair
- Justin Guinney
  • The First EHR DREAM Challenge: overcoming data access barriers in biomedical competitions - Thomas Schaffter and Tim Bergquist
  • A LightGBM Model to Predict 180 Days Mortality Using EHR Data - Jifan Gao  (Team UW-biostat)
1:30 pm 2:00 pm The Future of DREAM
Justin Guinney
2:00 pm 3:00 pm Networking


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Call for Top 10 Reading Papers, 2019



Coming soon.


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DREAM Submissions



Call for Papers for DREAM Conference Session and Poster

The DREAM Challenges are crowdsourcing challenges examining questions in biology and medicine. The DREAM Challenges are an open science effort of crowdsourcing challenges to examine questions in biology and medicine. We are a non-profit, collaborative community effort with contributors from across the research spectrum including universities; technology companies like IBM Research; not for profits, like Sage Bionetworks; and biotechnology and pharmaceutical companies. Since the beginning of the DREAM Challenges in 2006, we have been an innovator and leader in open science and crowdsourcing. The DREAM Challenge participants and organizers have numerous publications in top journals such as Science and Nature. Since the dawn of the DREAM Challenges, commercial crowdsourcing efforts have sprung up which utilize techniques that we pioneered.

Call for posters for DREAM Challenge Session
(we are currently accepting abstracts for posters for past DREAM Challenges)

View Open DREAM Challenges

We are excited to have a number challenges underway and a few will be part of this year’s conference so look forward to presentations and posters from these challenge’s participants.

Follow the links for each for the challenges to go that challenge’s pages to register and participate in the challenge to present at the conference.  Presenters for papers and posters will submit abstract information for the conference through the Synapse system used for their specific DREAM challenge. 

 

 

Preterm Birth Prediction: Transcriptomics DREAM Challenge

Using whole blood gene expression data collected from pregnant women, participants will develop models to predict gestational age at blood draw and risk of preterm birth.

 

CTD2 Beat AML DREAM Challenge

The goal of the Beat AML DREAM Challenge is to define patient subpopulations tailored to individual treatments by discovering (genomic and transcriptomic) biomarkers of drug sensitivity, as evaluated on an unpublished cohort of patients from the BeatAML project.

 

CTD2 Pancancer Drug Activity DREAM Challenge

Over the last two years, the Columbia CTD2 Center developed PANACEA (Pancancer Analysis of Chemical Entity Activity), a comprehensive repertoire of dose response curves and molecular profiles representative of cellular responses to drug perturbations. PANACEA covers a broad spectrum of cellular contexts representative of poor outcome malignancies, including rare ones such as GIST sarcoma and gastroenteropancreatic neuroendocrine tumors (GEP-NETs). The goal of the CTD2 Pancancer Drug Activity DREAM Challenge is to foster the development and benchmarking of algorithms to predict targets of chemotherapeutic compounds from post-treatment transcriptional data.

 

RA2 DREAM Challenge: Automated Scoring of Radiographic Joint Damage

Rheumatoid Arthritis (RA) is a debilitating disease that causes joint damage in the hands and feet due to inflammation. Accurate measuring of joint damage and progression of disease is essential in assessing the severity of disease, along with being able to monitor patient response to treatment. Scoring of X-ray images is tedious and there can be a great deal of variability between rheumatologists when applying scoring methods. We will leverage nearly 1000 images across a range of disease severities to challenge participants to develop an automated scoring algorithm with the goal of making clinical scoring fast and consistent; this will aid rheumatologists in making the best decisions for patients

 

Metadata Automation DREAM Challenge

We aim to significantly lower the burden of adding coherent metadata annotations across the data ecosystem to streamline and enable both retrospective harmonization as well as data query, discovery and interpretation. This challenge addresses this time-consuming task with automated metadata annotation of structured data.


DREAM Poster Track - The DREAM Challenges welcome poster submissions on past DREAM Challenges from groups who have done further retrospective data analysis on the Challenge data. The list of previous DREAM Challenges and links to their data is available here. We also welcome other challenge initiatives to present posters/talks at the DREAM session to share what they are doing and their experiences. We believe this conference is an opportunity to learn from one another on all aspects of the challenges of Challenges.

DREAM Posters deadline*: Sunday, November 1, 2020 or until capacity is reached
*Poster portal information will be sent on November 2nd to all approved posters. Poster and flask talk MUST be uploaded to the virtual platform NLT November 6th.


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Oral and Poster Presentation Submissions



Submit a Short Talk or Poster Presentation

The RECOMB/ISCB Conference on Regulatory and Systems Genomics invites abstracts for consideration for oral presentations or participation in a poster session. Abstracts may be either original unpublished work or original work that was published or accepted for publication in a high-impact journal between January 1, 2020 and November 1, 2020. Unpublished work will be considered for either an oral or poster presentation.

Key Dates:

  • Abstract Submission for Oral Presentation and Poster deadline: Monday, October 5, 2020
  • Author notifications will occur on or around Monday, October 19, 2020
  • Late Breaking Posters deadline*: Sunday, November 1, 2020 or until capacity is reached. 

*Poster portal information will be sent on November 2nd to all approved posters. Poster and flask talk MUST be uploaded to the virtual platform NLT November 6th.

Any abstracts submitted after the deadline will be included only at the discretion of the conference chairs, and will be eligible for poster presentations only. Please also note that we can only allow one abstract per presenting author.

Authors reserve the right to publish their work elsewhere.

Virtual Poster Hall: - When preparing accepted posters please note that your poster will need to be sent to us in two formats - a PDF of the poster and a 3-5 minute flash talk video not to exceed 100MB. 

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How to Submit Your Abstract

Please use this link to EasyChair to submit the text of your abstract (400 words or less). You will be asked to provide information about yourself and your coauthors, including name, email address, and affiliation. Please check one box for corresponding author to indicate who would be speaking or would be primarily responsible for your poster. You will also be asked to provide an abstract title, the text of your abstract, and keywords.

Click Here to Submit

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Topics

This conference is designed to present the latest findings about regulatory and systems genomics, foster discussion about current research directions, and establish new collaborations that will advance the development of a systems-level understanding of gene regulation. Some possible topics include:

  • Network visualization and analysis
  • Regulatory motifs and modules
  • Epigenomics and chromatin state
  • Non-coding RNAs
  • Regulatory networks
  • Co-transcriptional, post-transcriptional, and translational regulation
  • Signal transduction networks
  • Genetic, molecular, and phenotypic variation and human disease
  • Cellular signatures of biological responses and disease states
  • Mathematical modeling and simulation of biological systems
  • Methods for systematic validation of high-throughput biological predictions
  • Single-cell transcriptomics
  • Single-cell proteomics
  • Metabolomics
  • Microbiome
  • Machine learning methods for systems biology
  • Translational systems biology

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Special Session on Regulatory and Systems Genomics in Immunology

Regulatory and Systems Genomics 2020 will include an abstract submissions track for a Special Session of Cancer Systems. We welcome submissions on computational and experimental advances regulatory and systems genomics in immunology. Topics include but are not limited to: immunological regulatory programs and signaling pathways, genetic and non-genetic sources of self/non-self identification, precision epitope identification and targeting, and immune cell regulation. The session will include presentations from keynote speakers as well as talks from selected abstracts. This special session is sponsored by the Research Center for Cancer Systems Immunology at Memorial Sloan Kettering Cancer Center, an NCI-funded Cancer Systems Biology Consortium (CSBC) Center.

Click Here to Submit


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Getting Here and Around



Coming soon.


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Accommodations



Wyndham Pittsburgh University Center

The headquarters hotel for RSG 2020, The Wyndham Pittsburgh University Center is walking distance to Carnegie Mellon University and the University of Pittsburgh. Enjoy easy access to Oakland and other East End neighborhoods, a multitude of cultural destinations to include the Carnegie Museum of Natural History and the Phipps Conservatory and Botanical Gardens, and exciting shopping and dining.

Unwind at this 100% non-smoking hotel with plush bedding and modern conveniences including free WiFi, and make the most of your stay with our free area shuttle, heated indoor pool and fitness center, business center, and an onsite restaurant and lounge.

  • Room Rate: $109 for a Two Queen Standard per night
  • Includes complimentary WiFi, Fitness Center, Indoor Pool, and Free Shuttle to Local Attractions
  • Discount room rate available through October 23, 2020


Please use one of the following to book your reservation:

  • Please use this link to book online
  • Call for a reservation directly at 412-682-6250. Please reference 'RSGDREAM 2020'

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Welcome to the 13th annual RECOMB/ISCB Conference on Regulatory & Systems Genomics with DREAM Challenges



Now in its thirteenth year, the RECOMB/ISCB Conference on Regulatory and Systems Genomics with DREAM Challenges, is one of the premier annual meetings in the fields of regulatory genomics, systems biology, and network visualization. This multidisciplinary conference brings together both computational and experimental researchers from across the world to discuss recent discoveries about genomic and molecular regulatory networks as well as innovative, integrative methods for developing a systems-level understanding of biological activity.

The conference will be held as a Virtual ISCB Event. Program activities will begin on Monday, November 16, 2020 and conclude on Thursday, November 19, 2020

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Special Session on Regulatory and Systems Genomics in Immunology

Regulatory and Systems Genomics 2020 will include an abstract submissions track for a Special Session of Cancer Systems.  We welcome submissions on computational and experimental advances regulatory and systems genomics in immunology.  Topics include but are not limited to: immunological regulatory programs and signaling pathways, genetic and non-genetic sources of self/non-self identification, precision epitope identification and targeting, and immune cell regulation.  The session will include presentations from keynote speakers as well as talks from selected abstracts. This special session is sponsored by the Research Center for Cancer  Systems Immunology at Memorial Sloan Kettering Cancer Center, an NCI-funded Cancer Systems Biology Consortium (CSBC) Center.


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Exclusively for members

  • Member Discount

    ISCB Members enjoy discounts on conference registration (up to $150), journal subscriptions, book (25% off), and job center postings (free).

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