19th Annual International Conference on
Intelligent Systems for Molecular Biology and
10th European Conference on Computational Biology

Accepted Posters

Category 'K'- Institutional Research'
Poster K1
Partial Purification of Cellulase obtained from Tomato (Lycopersicon lycopersicum Karst) Fruits deteriorated by Aspergillus flavus Linn

Adesola Ajayi Covenant University
Short Abstract: Healthy ripe tomato fruits were inoculated with spores of Aspergillus flavus. The enzyme was partially purified by Ammonium Sulphate Precipitation, Gel filtration and Ion-exchange chromatography. The occurrence of Cellulase in tomato tissues infected by A.flavus and the absence of Cellulase in the non-infected tissues suggests a role for the enzyme.

Long Abstract: Click Here

Poster K2
The EMBL-EBI User Survey

Jennifer Cham EMBL-EBI
Rodrigo Lopez (EMBL-EBI, External Services); Graham Cameron (EMBL-EBI, Associate Director);
Short Abstract: The European Bioinformatics Institute (www.ebi.ac.uk) carried out an online survey of over 3,500 of its users throughout the world in October 2010. We wanted to identify who our users are and how they use our services, so that we can understand the way changes to our website may impact their research. We found that our users are split fairly evenly between bench and computational biologists; and for the most part, they visit our website to retrieve specific information from key databases. If we unify our look and feel and improve our navigation logic, this will help our existing users a great deal.
Poster K3
Identification of NMR Resonances Using EM Algorithms

Martin Krone Hochschule Braunschweig/Wolfenbuettel
Frank Klawonn (Hochschule Braunschweig/Wolfenbuettel, Computer Science); Christiane Ritter (Helmholtz Center for Infection Research, Structural Biology); Thorsten Luehrs (Helmholtz Center for Infection Research, Structural Biology);
Short Abstract: The computer-aided analysis of Nuclear Magnetic Resonances (NMR) data plays a critical role in modern NMR techniques.
One crucial step, for example in automatic protein NMR 3D structure determination, is the automated identification of resonances,
represented as two-dimensional intensities, so-called 'peaks', in the NMR spectra. The reliable identification of peaks still
represents a significant challenge owing to non-ideal peak-shapes, overlapping peaks and noisy data.

State of the art NMR applications require an automated and reliable spectra analysis. Currently available algorithms for peak picking
have several limitations, including very restricting assumptions on peak-shapes or the number of peaks.

We propose a novel idea to peak picking that is based on the Expectation Maximization (EM) algorithm.
This approach is implemented in a Java-based program which performs peak picking in an automated way,
but also allows user interaction by restarting the picking process using modified parameters if the user is not satisfied with the current results.

Instead of implementing the EM algorithm on our own, we exploit the R framework and its packages.
The communication between our program and R uses the Rserve implementation, a TCP/IP-based interface that allows us to install
our program on many computers with little effort while the computations will take place on a central and fast computer.

Initial tests show that the EM algorithm can indeed be applied to peak picking and also provides reasonable results on overlapping peaks.
Poster K4
In-silico analysis and prevention of Coksackie virus induced Insulin Dependent Diabetes Mellitus in human

Ambuj Kumar VIT
Mrinal Mishra (VIT, Bioinformatics); Kartikeya Agarwal (VIT, Bioinformatics); Dibyanshu Bhardwaj (VIT, Bioinformatics);
Short Abstract: There has been a multiple evidence of enteroviral infection reported in human which cause various diseases. The work is based on in-silico analysis of coksackie virus induced Insulin Dependent Diabetes Mellitus(IDDM) and the possible interactions between host and viral proteins.The infection of this coksackie virus strain has been reported to cause IDDM. The exact pathway of the viral-host protein interactions are still unknown. We used IntAct database and found that the viral VP4 protein interacts with the DAF proteins of Human beta cells. The DAF protein is responsible for prevention of compliment attacks in the host cell.The microarray data and the viral-host gene interaction pathways are used to understand the infection progression pathway. Protein-protein docking was used to obtain the locus for the viral protein(VP4) and host protein

(DAF) interaction (Etotal value -67.42 EShape value -62.36). The data obtained from protein-protein docking became the basis of this research. The amino acid involved in VP4-DAF interaction was found by analyzing the docked complex, using ArgusLab.The VP4 protein-drug complex failed to bind the beta cell DAF receptor. By using linkage maps we found the evolutionary linkage of coksackie virus B4 strain. This helped in gathering information about possible mutations in viral genome which was useful in designing the drug using Desloratadine as a template which could bind to conserved domain of VP4 protein near DAF binding site to prevent VP4-DAF interaction. The drug molecule was converted into pdb format and docked. We selected drug configuration showing least drug-protein complex E value after docking
Poster K5
The Hellenic Society for Computational Biology and Bioinformatics

Christos Ouzounis Computational Genomics Unit and Institute of Agrobiotechnology
Stavros Hamodrakas (University of Athens, Faculty of Biology, Department of Cell Biology and Biophysics); Ioannis Iliopoulos (University of Crete, Medical School); Pantelis Bagos (University of Central Greece, Department of Computer Science and Biomedical Informatics); Vasilis Promponas (University of Cyprus, Department of Biological Sciences);
Short Abstract: The Hellenic Society for Computational Biology and Bioinformatics (HSCBB) was conceived as a trans-national society, representing two countries that share the same language and history, Cyprus and Greece. The first, unofficial meeting was held in Heraklion (2006), followed by Athens and Thessalonica. After the formation of the Society and its ‘inaugural’, fourth scientific conference in Athens (2009), the HSCBB organized its next meeting in Alexandroupolis, with the aspiration to provide the necessary exposure of graduate students to new developments, expand its horizons towards the international community, promote the development of the field and formulate a solid agenda for the future, all consistent with its primary goals (http://www.hscbb.gr).

Thanks to the support of the local and regional authorities, the Democritus University of Thrace, the ENFIN Network of Excellence (enfin.org) and Biovista (http://www.biovista.com/), the HSCBB10 has been an unprecedented success, providing for the first time a clear picture of activities of the bioinformatics communities in the two countries. A wide range of topics were covered in HSCBB10 and selected posters have been further exposed at the F1000 (http://posters.f1000.com/PosterList?confID=110). Three internationally renown keynote speakers provided a wider perspective of translational bioinformatics in their own special fields.

We will present bibliometric data which indicate that bioinformatics have now taken root in Greece and Cyprus while there is still scope for growth. We hope that the effort of the HSCBB will ultimately generate the interest of the international community and establish a strong presence beyond the borders of Greece and Cyprus.
Poster K6
A Need for Specific, Advanced Topic Bioinformatics Training: The Canadian Bioinformatics Workshop Series

Michelle Brazas Ontario Institute for Cancer Research
Francis Ouellette (Ontario Institute for Cancer Research, Informatics and Biocomputing);
Short Abstract: Bioinformatics skills play a fundamental role in human and health research today, particularly as research projects produce increasingly larger data sets and require more complex data integration and analyses. A demand for advanced level bioinformatics skills that address topic specific research questions has resulted. However, finding adequate bioinformatic training programs that suit the specific needs and time constraints of researchers can be challenging.

The Canadian Bioinformatics Workshops (CBW), a national training program in computational biology established in 1999, continues to be successful in providing such advanced training opportunities because they have evolved with the bioinformatics needs of the research community. Community surveys and expert input taken annually, highlights user needs. In response to these needs, the CBW constantly updates and develops short two-day training sessions in specialized, advanced level topics. Topics covered thus remain relevant for research today, such as how to annotate a gene list and evaluate pathways (Pathway and Network Analysis from –omics Data workshop), and how to examine biological data and conduct essential statistical analyses such as hypothesis testing and clustering analysis (Exploratory Data Analysis and Essential Statistics using R workshop). Other topic areas have evolved to complement the growing number of high throughput experiments such as exploring the tools for evaluating metabolomic data (Informatics and Statistics for Metabolomics workshop) or microarray data (Microarray Data Analysis workshop) and how to manage and interpret HT sequencing data (Informatics on High-Throughput Sequencing Data workshop). Workshop specifics can be found at bioinformatics.ca
Poster K7
Spanish National Bioinformatics Institute (INB)

Allan Orozco Spanish National Bioinformatics Institute
Short Abstract: The Spanish National Bioinformatics Institute (INB) is a technological platform of the Carlos III Health Institute for the development of Genomic and Proteomic research and bioinformatics education in Spain. It’s a national institute that consists of nine nodes organized in science and technology areas of bioinfomatics and integrating a partnership with Barcelona Supercomputing Centre (BSC). The effort of the INB has been dedicated to the construction of a solid platform to facilitate the application of bioinformatics methods and support for projects in Genomics, Proteomics and Translational molecular medicine. Currently more then 30 bioinformaticians and computer scientists are employed by the institute. The INB has developed this infrastructure based on web services, including more that 400 specific methods for analysis and processing of biological data. Additionally, these web applications are particularly useful for biologists and bioinformaticians working in areas that require complex data analysis. On the tools side, the INB maintains a collection of software packages, including: 1) BABELOMICS 4, http://babelomics.bioinfo.cipf.es; 2) SNPator, http://www.snpator.org/; 3) GeneID, http://genome.crg.es/geneid.html; 4) INTOGEN, http://www.intogen.org; 5) CONTEXT, http://contexts.bioinfo.cnio.es/; 6) IWWEM, http://ubio.bioinfo.cnio.es/biotools/IWWEM/; 7) MODEL, http://mmb.pcb.ub.es/MODEL; 8) aGEM,http://bioinfoinb.cnb.csic.es/VisualOmics/aGEM and others.
The implemented infrastructure provides a general framework of generic solutions to several bioinformatics problems and support to national projects and international projects related to the Institute’s activities for the storage, access and exploration of biological data, that including: IMID-KIT (WGS of inflammatory diseases), AQUAGENOMICS (Marine Genomics), ESP-SOL (Tomato Genomics), OLIGEN (Plants Genomics) and others. Finally, The INB participates in the propose of the future European Bioinformatics Infrastructure (ELIXIR).

Accepted Posters

Attention Poster Authors: The ideal poster size should be max. 1.30 m (130 cm) high x 0.90 m (90 cm) wide. Fasteners (Velcro / double sided tape) will be provided at the site, please DO NOT bring tape, tacks or pins. View a diagram of the the poster board here

Posters Display Schedule:

Odd Numbered posters:
  • Set-up timeframe: Sunday, July 17, 7:30 a.m. - 10:00 a.m.
  • Author poster presentations: Monday, July 18, 12:40 p.m. - 2:30 p.m.
  • Removal timeframe: Monday, July 18, 2:30 p.m. - 3:30 p.m.*
Even Numbered posters:
  • Set-up timeframe: Monday, July 18, 3:30 p.m. - 4:30 p.m.
  • Author poster presentations: Tuesday, July 19, 12:40 p.m. - 2:30 p.m.
  • Removal timeframe: Tuesday, July 19, 2:30 p.m. - 4:00 p.m.*
* Posters that are not removed by the designated time may be taken down by the organizers and discarded. Please be sure to remove your poster within the stated timeframe.

Delegate Posters Viewing Schedule

Odd Numbered posters:
On display Sunday, July 17, 10:00 a.m. through Monday, June 18, 2:30 p.m.
Author presentations will take place Monday, July 18: 12:40 p.m.-2:30 p.m.

Even Numbered posters:
On display Monday, July 18, 4:30 p.m. through Tuesday, June 19, 2:30 p.m.
Author presentations will take place Tuesday, July 19: 12:40 p.m.-2:30 p.m

Want to print a poster in Vienna - try these options:

Repacopy- next to the congress venue link [MAP]

Also at Karlsplatz is in the Ring Center, Kärntner Str. 42, link [MAP]

If you need your poster on a thicker material, you may also use a plotter service next to Karlsplatz: http://schiessling.at/portfolio/

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