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Volume 8, Issue 3
President's
Letter
Rost To Become
Next ISCB President
Rocky'05 Bioinformatics
Conference Colorado
in December
Update on
PLoS Computational Biology
Putting Students
in the Spotlight
Call for 2006
Awards Nominations
ISMB 2006 in Brazil
New ISCB Membership
Site
Now Open
ISMB 2006
Call for Tutorials
RECOMB 2006 Registration Opening This Week
ISMB 2005 SIGs Recap
Israeli Bioinformatics Symposium
2005
A Prelude to ECCB’06
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Upcoming Events
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News from the Field
Acknowledgements
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| ISMB
2005 Special Interest Groups Meeting Recaps
Seven Special Interest Groups (SIGs) met in conjunction
with ISMB 2005 in Detroit, Michigan, this past summer. Each year
ISCB invites select SIGs to share a summary of their meetings with
our readers as a means of potentially expanding awareness of their
work both during the conference and throughout the year. Below is
a recap of three such SIGs from 2005.
Automated Function Prediction 2005 SIG Summary
Submitted by Iddo Friedberg, Martin Jambon and
Adam Godzik
Automated function prediction is maturing into
a sub-field of its own within computational biology. On the one
hand, with all the data coming in from various genomics projects,
there is a dire need for annotation of genes and gene products.
On the other hand, the computational biology community has just
begun to recognize the need for bona fide automated annotators:
algorithms that are capable of receiving sequence or structure data
and producing a succinct function prediction, and doing so not only
by homology based methods. Furthermore, with the emerging predictors,
comes the need for assessment: how well are the function predictors
doing?
The first Automated Function prediction SIG meeting
was set up as focal point for the various research groups involved
in this new and exciting field. The 17 talks that were given discussed
the various aspects of computationally predicting function from
sequence, function from protein 3D structure, function from genomic
context, and the ways and means of assessing the quality of function
prediction programs. The response from leading researchers was extraordinary,
with Michael Sternberg from Imperial College delivering a keynote
talk, and Olivier Lichtarge (Baylor College of Medicine), Russ Altman
(Stanford University), Patricia Babbitt (UC San Francisco) and Adam
Godzik (The Burnham Institute) leading plenary sessions on predicting
function from structure, context based predictions, analysis of
function site, functional diversity, and challenging the servers.
Server challenge was done by Martin Jambon and Iddo Friedberg from
The Burnham Institute, and reported by Iddo Friedberg. A poster
session and lively discussions on the various aspects of this emerging
field served to enhance this exciting day.
With 89 registrants and a head count of over 100
attendees, the one day meeting was considered extremely successful.
It was agreed that function prediction is indeed a distinct field,
and that there is a scientific community which is interested in
meeting regularly to discuss and develop it. Excerpts from the meeting
will be published in Protein Science in early 2006. More information
can be found at: http://ffas.burnham.org/AFP.
BioLINK 2005 SIG Summary
Submitted by Christian Blaschke,
Kevin Cohen, Lynette Hirschman and Hagit Shatkay:
BioLINK SIG co-organizers
BioLINK SIG is concerned with the rapidly maturing field of biomedical
text mining: using techniques from natural language processing,
information extraction and information retrieval to automate knowledge
discovery from the biomedical literature and free text.
This was the fifth consecutive BioLINK SIG at ISMB, and the first
time that it was held jointly with the Workshop on Linking Biological
Literature, Ontologies and Databases of the Association for Computational
Linguistics (ACL), whose annual conference took place in parallel
to ISMB in neighboring Ann Arbor. The joint meeting was the largest
BioLINK SIG so far (about 100 people in the audience), and attracted
many excellent full-length and short papers, posters and talks.
All papers, both long and short, went through a full peer-review
process. Eight full-length papers were accepted out of 18 full-paper
submissions; these were presented and published in the ACL Workshop
proceedings. Additionally, 9 short papers were accepted out of 21
short submissions and included in the SIG handouts; 5 of them were
selected for presentation during the workshop as short talks, for
a total of 13 research talks.
The keynote speaker was Dr. Judith A. Blake, who is one of the leaders
of the Mouse Genome Informatics Group at the Jackson Laboratories
and a co-founder of the Gene Ontology Consortium. She presented
a fascinating talk about the current challenges of integrating biomedical
literature with bioinformatics and genomics information, to support
curation of model organism databases. This successful meeting concluded
with a lively poster session of 22 selected posters, followed by
dinner at Detroit’s Greek Town. We would like to thank the
many people who helped in organization and review, and particularly
Steven Leard for his outstanding organizational support for the
SIGs. We are looking forward to next year’s meeting in Brazil.
Bioinformatics Open-Source Conference SIG
Summary
Submitted by Darin London
The Bioinformatics Open-Source Conference (BOSC)
is held annually as a Special Interest Group with the Intelligent
Systems for Molecular Biology (ISMB) conference, hosted by the Open
Bioinformatics Foundation (www.open-bio.org).
The aims of the conference are: to showcase the work of projects
devoted to creating open-source bioinformatics software, or open
standards of communication and information management; to facilitate
communication and interaction between developers working within
projects, and between project members and members of the wider community
interested in their projects; and educate the research community
on the value of open-source software and open standards. The meeting
consists of keynote speakers invited by the BOSC organizing committee
for outstanding achievements in Bioinformatics, Open-Source development,
or overall research skill; twenty-minute presentations selected
from a competetive pool of abstracts submitted for consideration;
five-minute lightning-talks and software demonstrations; and Birds
of a Feather meetings on specific projects or areas of interest.
BOSC 2005 included two keynote speakers: Jason
Stajich, a key developer of the very popular BioPerl software package,
and Hilmar Lapp, speaking on behalf of the Open Bioinformatics Foundation.
Mr. Stajich's talk, 'Building Bioperl: lessons for Open-Source and
Bioinformatics', presented an historical summary of the development
of the BioPerl system, demonstrating the evolution of typical open-source
software projects, and the challenges they face. Dr. Lapp presented
the new organizational structure of the Open Bioinformatics Foundation
as a not-for-profit organization with memberships open to all those
who support their mission at no charge. All participants of BOSC
2005 were given the opportunity to become
members, and participate in shaping the future direction of the
foundation.
The full length talk lineup included 15 speakers
whose abstracts were chosen from a very competitive group. They
demonstrate the diversity and quality of work being done in the
open-source bioinformatics community. Highlights include talks on
a variety of new tools for managing bioinformatics analyses, and
result visualization; discussions of a number of powerful data-mining
systems; and many tools designed to use or manage an ever expanding
list of web services for bioinformatics. The schedule for BOSC 2005,
including links to abstracts, images, and slides, can be accessed
at http://open-bio.org/bosc2005/finalProgram.
Preparation for BOSC 2006 in Brazil is already
underway. Check the OBF website (www.open-bio.org)
for more details.

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