|2015 ISCB Accomplishment by a Senior Scientist Award: Cyrus Chothia|
The ISCB Senior Scientist Accomplishment Award recognizes leaders in computational biology and bioinformatics for their significant contributions to these fields through research, education, and service.
Cyrus Chothia was selected as the 2015 recipient for his groundbreaking work using computation to understand protein structure and function and the evolution of genomes. Chothia is well known for using computation to study protein structure, and his early work showed that relatively simple principles govern the structure of proteins, regardless of the structural complexity. His research has been critical to understanding and classifying proteins based on structural folds, and he has shown that changes to a protein sequence can be accommodated by structural shifts. More recently, Chothia developed computational approaches based on his knowledge of protein structure to understand how gene duplication and recombination between particular domains drives genome evolution. Chothia’s illustrious career includes election as a Fellow of the Royal Society in 2000. He has mentored numerous students and postdoctoral fellows, and many are now rising leaders in their respective fields. Chothia’s work throughout his career has been instrumental to the birth of the fields of structural bioinformatics and computational genomics.