Director of The Sudarsky Center for Computational Biology
Department of Biological Chemistry
Institute of Life Sciences
The Hebrew University of Jerusalem, Israel
Presentation Title: TBA
Presentation Time: Sunday, July 13,¬† 9:00 am - 10:00 am
Isaac (Zak) Kohane is the director of the Children‚Äôs Hospital Informatics Program and is the Henderson Professor of Pediatrics and Health Sciences and Technology at Harvard Medical School (HMS). He is also the co-Director of the HMS Center for Biomedical Informatics and Director of the HMS Countway Library of Medicine. Dr. Kohane leads multiple collaborations at Harvard Medical School and its hospital affiliates in the use of genomics and computer science to study diseases (particularly cancer and autism) through the perspective of biological development. He also has developed several computer systems to allow multiple hospital systems to be used as ‚Äúliving laboratories‚ÄĚ to study the genetic basis of disease while preserving patient privacy. Among these, the i2b2 (Informatics for Integrating Biology and the Bedside) National Computing Center has been deployed at over 52 academic health centers internationally.
Dr. Kohane has published over 200 papers in the medical literature and authored a widely used book on Microarrays for an Integrative Genomics. He has been elected to multiple honor societies including the American Society for Clinical Investigation, the American College of Medical Informatics, and the Institute of Medicine. He leads a doctoral program in genomics and bioinformatics at the Division of Health Sciences and Technology at Harvard and MIT. He is also a practicing pediatric endocrinologist and father of three energetic children.
¬†2014 ISCB Accomplishment by a Senior Scientist Award
Eugene (Gene) Myers
Director and Tschira Chair of Systems Biology
Max Planck Institute of Molecular Cell Biology and Genetics
Presentation Title: DNA Assembly: Past, Present, and Future
Presentation Time: Sunday, July 13,¬† 4:40 pm - 5:40 pm
In the 80's Gene Myers developed many efficient algorithms for sequence comparison and search, used, for example, in BLAST and UNIX diff. With Udi Manber, he invented suffix arrays that enable the Burroughs-Wheeler transform needed in todays space-efficient indices, especially for genomic data. Myers developed the overlap-layout-consensus paradigm for DNA sequencing, ultimately perfecting the string graph approach used at Celera to successfully assemble the fly, human, and mouse genomes. With Jim Weber, he was the first to propose paired-end whole genome shotgun sequencing of the human genome, the paradigm by which most genomes are sequenced today. Recently he has focused on the construction of novel microscopes and software for building single cell expression atlases across developmental epochs.
Myers has been a professor at U of Arizona and UC Berkeley, a vice president at Celera Genomics, and a group leader for HHMI and the Max-Planck Society. He is a member of the National Academy of Engineering, USA, the National Academy of Germany, and won the ACM Kannellakis Prize in 2002.
Isaac (Zak) Kohane MD, PhD
Director, Children‚Äôs Hospital Informatics Program
Henderson Professor of Pediatrics and Health Sciences and Technology
Harvard Medical School and Children‚Äôs Hospital Boston
Director, Countway Library of Medicine
Director, i2b2 National Center for Biomedical Computing
Co-Director, HMS Center for Biomedical Informatics
Presentation Title: TBA
Presentation Time: Monday, July 14,¬† 9:00 am - 10:00 pm
Michal Linial is a Professor of Biochemistry, Molecular Biology and Bioinformatics at the Hebrew University of Jerusalem, Israel, where she heads the Israel Institute for Advanced Studies.
She received her PhD from the Hebrew University's Medical School (1986) in Biochemistry and Molecular Biology. During her post-doctoral training in Stanford University, she engaged in molecular neuroscience with the goal of deciphering the molecular makeup of the synapse. She joined the Hebrew University (1989) and was a driving force in merging computational and analytical tools with classical wet biology. She is a founder (1999) and the chair of the undergraduate and graduate joint program in Computer sciences and Life Sciences at the Hebrew University. She heads The Sudarsky Center for Computational Biology at the Hebrew University.
Her laboratory is active in the two arenas - She leads a wet lab as well as a computational group. Her research interests span a broad range of topics such as stem cells, neuronal differentiation, synapse regulation, cell biology of secretory systems and the molecular mechanisms that underlie behavior and metabolic diseases. With the maturation of large-scale technologies, she has become involved in developing methods for target selection in Structural Genomics, protein family classification and the development of methodologies for the analysis of large-scale biological data sets. She is particularly interested in introducing powerful computational tools to meet the needs of the biological and bio-medical research communities. Among the web tools developed by her research group are PANDORA, ProtoNet, and EVEREST. One of her main recent areas of activity is proteomics where she combines experimental, technological and computational work.
She is an ISCB‚Äôs vice-president, a member of its Board of Directors, and is active in the Conference and Education committees and the ISCB Students‚Äô council. She served as the Chair of the European Conference in Computational Biology, and a member of the steering committees of RECOMB and ECCB.
Department of Biological Sciences
New York, United States
Presentation Title: ¬†A multidimensional single cell approach TO understand cellular behavior
Presentation Time: Monday, July 14,¬† 4:45 pm - 5:45 pm
Department of Chemical Engineering
Massachusetts Institute of Technology
Cambridge, United States
Presentation Title: TBA
Presentation Time: Tuesday July 15, 9:00 am - 10:00 pm
Robert Langer is an Institute Professor at MIT (there are 11 Institute Professors at MIT; being an Institute Professor is the highest honor that can be awarded to a faculty member). His h-index of 153 is the highest of any engineer in history and he has 1,026 issued and pending patents worldwide. His patents have licensed or sublicensed to over 250 companies. He served as Chairman of the FDA‚Äôs SCIENCE BOARD (it‚Äôs highest advisory board) from 1999-2002. Langer is also one of only 3 individuals ever elected to the Institute of Medicine of the National Academy of Sciences, the National Academy of Engineering, the National Academy of Sciences and the National Academy of Inventors. He is one of only seven people to ever receive both the United States National Medal of Science and the United States National Medal of Technology and Innovation. He has also received the Charles Stark Draper Prize (considered the engineering Nobel Prize), Albany Medical Center Prize, the Wolf Prize for Chemistry, the Millennium Technology Prize, the Priestley Medal (highest award of the American Chemical Society), the Gairdner Prize and the Lemelson-MIT prize, for being ‚Äúone of history‚Äôs most prolific inventors in medicine.‚ÄĚ He holds 21 honorary doctorates including honorary degrees from Harvard and Yale.
2014 ISCB Fellows Keynote
Professor of Bioengineering, Genetics, and Medicine and Computer Science
Director, Biomedical Informatics Training Program
Stanford University, United States
Presentation Title: TBA
Presentation Time: Tuesday, July 15, 4:40 pm - 5:40 pm
Russ Biagio Altman is a professor of bioengineering, genetics, & medicine (and of computer science, by courtesy) and past chairman of the Bioengineering Department at Stanford University. His primary research interests are in the application of computing and informatics technologies to basic biological problems relevant to medicine. He is particularly interested in methods for understanding drug action at molecular, cellular, organism and population levels. His lab studies how human genetic variation impacts drug response (e.g. http://www.pharmgkb.org/). Other work focuses on the analysis of biological molecules to understand the action, interaction and adverse events of drugs (http://features.stanford.edu/). He leads one of seven NIH-supported National Centers for Biomedical Computation, focusing on physics-based simulation of biological structures (http://simbios.stanford.edu/). Dr. Altman holds an A.B. from Harvard College, and M.D. from Stanford Medical School, and a Ph.D. in Medical Information Sciences from Stanford. He received the U.S. Presidential Early Career Award for Scientists and Engineers and a National Science Foundation CAREER Award. He is a fellow of the American College of Physicians, the American College of Medical Informatics, and the American Institute of Medical and Biological Engineering. He is a member of the Institute of Medicine of the National Academies. He is a past-president, founding board member, and a Fellow of the International Society for Computational Biology, and the President-Elect of the American Society for Clinical Pharmacology & Therapeutics. He currently chairs the Science Board advising the FDA Commissioner. He is an organizer of the annual Pacific Symposium on Biocomputing (http://psb.stanford.edu/), and a founder of Personalis, Inc. He won the Stanford Medical School graduate teaching award in 2000.