Leading Professional Society for Computational Biology and Bioinformatics
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  • Affiliated Groups

    The ISCB Affiliates program is designed to forge links between ISCB and regional non-profit membership groups, centers, institutes and networks that involve researchers from various institutions and/or organizations within a defined geographic region involved in the advancement of bioinformatics. Such groups have regular meetings either in person or online, and an organizing body in the form of a board of directors or steering committee. If you are interested in affiliating your regional membership group, center, institute or network with ISCB, please review these guidelines (.pdf) and send your exploratory questions to Diane E. Kovats, ISCB Chief Executive Officer (This email address is being protected from spambots. You need JavaScript enabled to view it.).  For information about the Affilliates Committee click here.

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    Topically-focused collaborative communities

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Professional Development, Training, and Education

ISCBintel and Achievements

Art in Science Exhibit Hall



Click on the thumbnails to view full-scale


Art of Epigenetics, Zdenko Herceg, Mixed media canvas painting (162x130 cm) 2020
by Dr. Zdenko Herceg

Science and Art are two sisters born to passion, the one choosing a relentless quest for truth and the other opting for eternal search of beauty and meaning. Sisterly encounters, even though rare, are impregnated with creative tensions and inspiring alliances poised to reveal secrets of life. Epigenetics is art of interpreting the genetic code where epigenetic modifying enzymes impersonate the artists that use a panoply of colors, forms and shapes to decrypt the DNA heritage and to portray molecular imprints of nature and nurture. United in an art club, the writers (HA-W, HM-W and DM-W), readers (HA-R, HM-R and DM-R) and editors (HA-E, HM-E and DM-E) dynamically brush the tentacles of the epigenetic octopus (octamer of histones) that embodies the diversity, adaptability, mystery and intelligence. We are taking a deep dive to unveil the buried treasure map decoding the language of our genes and diary imprinted by our life and environment in a fascinating story of underwater adventures (aqueous state of the cell) to uncover the shelter hiding the cancer and the shell safeguarding those willing to take the adventure.

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Impact
by Mr. Joshua Bugbee

The multi-dimensional effects of COVID-19. Our world has been changed forever.

 

 

 

 

 

 

 

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Brain Vasculature
by Dr. Marwan Abdellah

An artistic rendering of a digital reconstruction of the human brain arterial arborizations.

Dataset is available from the Brain Vasculature (BraVa) database. The mesh reconstruction is performed with NeuroMorphoVis and the rendering is obtained with Cycles.

 

 

 

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Genome Graphs
by Mr. David Twesigomwe

The concept of graphs was born from the intriguing Königsberg bridge math problem. Currently, there is an ongoing paradigm shift in genetic variant detection, characterised by applying the concept of graphs to create reference pangenomes rather than relying on linear reference sequences.

Even though standard approaches for detecting small nucleotide changes as well as structural variants based on alignment to linear reference genomes have largely been successful, they face a number of limitations. Linear reference genomes are not representative of a number of minority world populations. Their structure does not allow for capturing genetic diversity especially in complex genomic regions. They also present a challenge of reference allele bias during read mapping as well as potential misalignments around indels.

Genome graphs offer an interesting solution to these challenges by enabling augmentation of linear references with virtually any form of variation using nodes connected by edges as shown in this artwork. In this way, various alleles in a population can be represented as paths in the graph thus allowing for better read mapping and variant detection.

This artwork was produced using an open source graphical assembly visualisation tool called ‘Bandage’ (https://rrwick.github.io/Bandage/)

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Tumor Biomarker Heatmap
by Mr. Joshua Bugbee

This is no ordinary heatmap, this takes into consideration the trajectories of change for given biomarkers, better producing a clear picture of the dynamics within a tumor microenvironment.

 

 


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Logic Gates
by Mr. Joshua Bugbee

The use of these tools are absolutely necessary to fold into our everyday instruments to evaluate such complex processes - especially under the auspices of complex adaptive systems and the importance of state changes regarding dynamic temporal events.

 

 

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Tensor Decomposition
by Joshua Bugbee

The use of tensors is just getting started. Revealing insights into more complex biological processes is a cornerstone. This simplistic rendition of that fact is not to minimize what they do at present, but to foreshadow what they will help reveal in the future.

 

 

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listen
by Mr. Joshua Bugbee

It is challenging to arrive at the true signal present amongst a deluge of noise. Listen closely.

 

 

 

 

 


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Nash
by Mr. Joshua Bugbee

Notions such as game theory need to be superimposed onto our observations of cancer treatments to really understand the economic truites associated with these systems and subsystems and how we can better exploit the flaws that will lead us to saving more lives, faster.

 

 

 

 

 


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Barchart Deconstruction
by Mr. Joshua Bugbee

The simplistic use of various tools like barcharts are evolving into more complex ways of understanding higher dimensional data. While science itself evolves, so must the metrics that we use.

 

 

 

 

 

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Robust Network
by Mr. Joshua Bugbee

Despite the perturbations provoking various systems, robust networks emerge and evolve. The underlying dynamics of the perturbations and how said system reacts can be observed at varying scales of the network, allowing the creation of more effective therapeutic mechanisms.

 

 

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Nodal Interference
by Mr. Joshua Bugbee

The interpretation and mechanistic understanding of the blockage of various driver nodes within a system, like the energy transduction systems of various cancers, will lead to better enhanced precision therapeutics regarding tumor clonal evolution and associated treatment strategies.

 

 

 

 

 


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Avatars of breast cancer cells
by Dr. Heba Sailem

Cancer cells are highly heterogenous even when they share the same genetic background. Here we illustrate the morphological heterogeneity of breast cancer cells using PhenoPlot. PhenoPlot is an automated visualisation tool that draws a quantitative pictorial representation (avatars) of cells based on the quantification of thousands of cells. We represent various shape features of single breast cancer MCF7 cells are represented to demonstrate their heterogeneity. The dimensions of cells and their nuclei are reflected in ellipse height and width. The irregularity in the cell membrane is represented by the extent of the jagged line surrounding the ellipse. The thick part of the cell border reflects the extent of cell-cell contact. The intensity of DAPI (nuclear marker) and DHE (cytoplasmic marker) are represented using colour hues. Collectively nine dimensions are represented. PhenoPlot can be an effective science communication tool as it simplifies complex data to lay audience.

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Protein 2D structures
by Mr. Aleix Lafita-Masip

Proteins fold into complicated three dimensional molecules. As we also happen to exist in 3D, we feel the need to rotate them around in our 2D computer screens all the time. Commonly, our goal is to see which residues of the protein interact and how the protein chain is threaded, so we can compare different proteins and understand their function. Would it not be easier if protein structures were in two dimensions?
Here, I used a slight variation of our protein modelling approach based on Euclidean Distance Matrices (EDMs) to produce 2D structures of proteins. Preserving only close distances between residues in the protein distance matrix, it is possible to apply a technique known as multidimensional scaling to map atomic coordinates in 2D. The resulting structures preserve information on residue interactions and fold topology, useful for protein structure analysis, with the advantage of being in two dimensions.
Do you recognise any of these domain folds?

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Coiling and Clustering
by Robin Aguilar

Observing data trends leads to new questions and inspires discovery. Data visualization tools have many applications and implications in the field of bioinformatics. In this piece, "Coiling and Clustering", many techniques of data visualization are highlighted. The watercolor galaxy background was created by a Generative Adversial Network (GAN) trained with space and galaxy images that were merged with super resolution microscopy and watercolor textures. GANs have been applied to the field of bioinformatics to learn new insights on gene expression profiles and how the genome is organized. The clusters of multicolored dots represent the concept of dimensional reduction such as those presented in clustering methods like UMAP/t-SNE projections of single cell measurements. And lastly, the snake featured is a python, representing a common language and ground used by researchers for extensive data science and bioinformatics applications.

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Diving into the Visual Cortex
by Dr. Marwan Abdellah

In silico visualization of a little block of neurons reconstructed from the visual cortex of the 36-day-old mouse with electron microscopy.

The dataset is available from:
 Seung Lab - Princeton University
Brain-map.org - Allen Institute for Brain Science
Tolias Lab - Baylor College of Medicine
IARPA Microns

 

 

 

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Brain Vasculature
by Dr. Marwan Abdellah

A high-quality rendering of a large vasculature mesh generated from a vascular graph of a mouse brain. The image is created automatically with VessMorphoVis (BioVis).

Dataset Courtesy of Bruno Weber (University of Zurich)

 

 

 

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multiplE seQUence ALignment
by Dr. Debswapna Bhattacharya

Multiple sequence alignment represents a powerful method to unify seemingly diverse biological sequences and considered as one of the most widely used approaches in bioinformatics. By taking into account evolutionary events such as mutations, insertions, and deletions (that appear as hyphens), multiple sequence alignment, in its original form, symbolizes diversity.

Here, we use grayscale to represent a hypothetical multiple sequence alignment with systemic deletions to remind ourselves of the inEQUALity that exists in our society and to recommit ourselves to eradicating it wherever it is found.

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ISMB 2020 Slack Channels



Virtual discussion with attendees for ISMB 2020 is going through slack for the virtual event. Not on slack? Click here to get started!

Find the Channel for the track discussion you want to join in the lists below and use the link to join.


General Channels

ISCB
Communities of Special Interest

COSI Channels

3D-SIG: Structural Bioinformatics and Computational Biophysics

BIOINFO-CORE Bio-Ontologies
BioVis: Biological Data Visualizations

BOSC: Bioinformatics Open Source Conference CAMDA: Critical Assessment of Massive Data Analysis
CompMS: Computational Mass Spectrometry Education: Computational Biology and Bioinformatics Education and Training
EvolCompGen: Evolution & Comparative Genomics
Function: Gene and Protein Function Annotation HiTSeq: High Throughput Sequencing Algorithms & Applications
iRNA: Integrative RNA Biology
JPI: Junior Principal Investigators MLCSB: Machine Learning in Computational and Systems Biology
Microbiome
NetBio: Network Biology RegSys: Regulatory and Systems Genomics
SysMod: Computational Modeling of Biological Systems
Text Mining TransMed: Translational Medicine Informatics & Applications
VarI: Variant Interpretation

Special Sessions

Special Session 01:
Systems Immunology: Computational approaches for understanding human immune system and immune-related diseases
Special Session 02:
Bioinformatics outside the lab: How to mobilize online citizen scientists to accelerate research
Special Session 03:
Bioinformatics of Corals
Special Session 04:
SCANGEN: Single-cell cancer genomics
Special Session 05:
HuBMAP: Integrating genomics, imaging and mass-spectrometry to construct single-cell human tissue maps
Special Session 06:
Interpreting the Lipidome – Approaches to Embrace the Complexity
  Special Session 07:
The Brain Initiative Cell Census Network
 

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Bioinformatics Bazaar

Bioinformatics Bazaar is designed to showcase products, software, tools, and services of interest to the greater bioinformatics and computational biology community. The products, services, and tools included in this directory are crowd-sourced. The content provided and placement of offerings within this section should not be considered endorsements of ISCB.

Links within this page: Publishing | Degree Programs/Careers/Recruiting | Tools/Software | Databases | Services | Hardware | Professional Societies/Organized Groups


Publishing

 




(Click to download)
F1000Reseach
f1000research.com


F1000Research is an Open Research publishing platform for scientists, scholars and clinicians offering rapid publication of articles and other research outputs without editorial bias. All articles benefit from transparent peer review and editorial guidance on making all source data openly available.
Oxford University Press
https://academic.oup.com/BIOINFORMATICS

Bioinformatics publishes the highest quality scientific papers and review articles with its main focus is on new developments in genome bioinformatics and computational biology.
 




(Click to download)


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Degree Programs/Careers/Recruitiung

 



(click to download)
Harvard Medical School, Biomedical Informatics
http://dbmi.hms.harvard.edu/

The Harvard Medical School Department of Biomedical Informatics offers a variety of opportunities to increase your knowledge base and skill set in the application of quantitative principles to biomedical discovery. Programs include a Master’s, PhD, and Summer Institute. To learn more about these programs as well as postdoctoral fellowships and software engineering opportunities, please visit: http://dbmi.hms.harvard.edu/
Janssen Immunology
https://www.janssen.com/

Janssen Research & Development, LLC is a part of the Janssen Pharmaceutical Companies of Johnson & Johnson. The mission of our immunology therapeutic area is to redefine treatments for immune diseases by delivering transformational and accessible therapies and regimens to patients with autoimmune disease.
 



(Click to download)
  The Jackson Laboratory
https://www.jax.org/


JAX uniquely amplifies the efforts of the global biomedical research community. We develop and share our research, innovative tools and solutions, ever‑expanding data resources, more than 11,000 specialized mouse models and services, and a suite comprehensive educational programs to empower basic scientific research and speed drug discovery across the globe.


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Tools/Software

  Gene Pattern Notebook
https://notebook.genepattern.org/


The GenePattern Notebook environment, notebook.genepattern.org, integrates the Jupyter Notebook system with the GenePattern platform for integrative genomics analysis, making hundreds of analyses available within notebooks without the need for programming. Additional features allow publication and collaboration. A library of useful analysis notebook templates can be adapted to a scientist's needs.
Expression Atlas
https://www.ebi.ac.uk/gxa/home

Expression Atlas at EMBL-EBI provides free resources that facilitate submission, archival, reprocessing and visualisation of functional genomics data. This allows researchers a powerful way to identify where their favourite gene is expressed and how its expression changes in disease. Our tools are continuously updated to incorporate datasets using new technologies.


 
  HiSCiAp
https://usegalaxy.eu/

HiSCiAp is a user-friendly Galaxy setup to use ~80 Single Cell analysis modules from tools such as a Seurat, Scanpy, Monocle3, SCMap and others in QC, clustering, trajectory analysis and cell mapping. Tools are available at humancellatlas.usegalaxy.eu, can be installed on any Galaxy instance or used in command line.


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Databases

  NIH ODSS
https://datascience.nih.gov/


The Office of Data Science Strategy (ODSS) leads implementation of the NIH Strategic Plan for Data Science through scientific, technical, and operational collaboration with the institutes, centers, and offices that comprise NIH. The office was formed in 2018 within the Division of Program Coordination, Planning, and Strategic Initiatives, which plans and coordinates trans-NIH initiatives and research supported by the NIH Common Fund.


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Services

  None posted yet.


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Hardware

  None posted yet.


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Professional Societies/Organized Groups

 





(Click to download)
The Black Women in Computational Biology Network
https://www.blackwomencompbio.org/
Twitter: https://twitter.com/blkwomencompbio?lang=en

The Black Women in Computational Biology Network is an intersectional community of Black women who are working toward (or interested in) a career that combines computational and quantitative sciences with Biology. Our community is comprised of women across all degree and professional levels from an array of backgrounds in biology, computer science, mathematics, bioengineering, chemistry, physics, medicine, public health data science, and much more refining their unique skillset to answer biological questions through a computational and quantitative lens.
Folks in GCB
https://www.folksingcb.com/

Inspired by The Roster of Women & Minorities in Physics, #womenalsoknowstuff, and, especially, DiversifyEEB, Folks in GCB was founded in the Summer of 2017 to highlight folks in the fields of genomics, computational biology, and bioinformatics (GCB) who are not traditionally represented in these fields.

Folks in GCB is a self-nomination list for individuals from groups that are underrepresented in the genomics, computational biology, or bioinformatics community, which is in itself highly context-specific. It is designed to be a reference when looking for expert speakers or reviewers, for example, rather than an active community effort.
 
  International Society for Computational Biology
www.iscb.org

The International Society for Computational Biology
(ISCB) (www.iscb.org) was the first and continues to be the only society representing computational biology and bioinformatics worldwide. ISCB serves a global community of nearly 3,400 scientists dedicated to advancing the scientific understanding of living systems through computation by:
  • convening the world’s experts and future leaders in top conferences
  • partnering with publications that promote discovery and expand access to computational biology and bioinformatics
  • delivering valuable information about training, education, employment, and relevant news
  • providing an influential voice on government and scientific policies that are important to our members
ISCB has two official journals – OUP Bioinformatics and F1000Research ISCB Community Journal, and has affiliations in place with several other publications for the benefit of our members.
ISCB Student Council
www.iscbsc.org

ISCB Student Council (SC, www.iscbsc.org) is an international network of young researchers in the broader disciplines of the field of Computational Biology. SC provides opportunities for networking, career enhancement and skills development for the next generation of Computational Biology leaders. The SC Symposium (symposium.iscbsc.org) is organized as a part of the annual ISMB conference with student presentations, keynotes, panel discussions and a poster session. Come visit our friendly SC representatives at the booth for more information.
 
  GOBLET
www.mygoblet.org

GOBLET, the Global Organisation for Bioinformatics Learning, Education and Training, is a legally registered foundation whose mission is to cultivate the global bioinformatics trainer community, set standards and provide high-quality resources to support learning, education and training. GOBLET main objectives are: for the training portal to become both a pull mechanism and repository; to offer training for trainers and end-users; to develop training material and course standards; to provide training resources (surveys, best-practice guidelines, etc.); to raise funds to be able to meet our objectives; to offer a network/community forum; to give further consideration to mechanisms for trainer recognition.


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Exploring Montréal from Home



It’s sad that we cannot be gathered together in Montreal to experience the city, our science, and see our friends and colleagues. To help ease the pain, Tourisme Montréal has compiled a list of some of the best online activities, including virtual city tours, music, games and more which feature the city. ISMB will be going back to Montreal in 2024 but until then, enjoy these activities.


Montréal food

We know you are missing the regional cuisine of the Quebec province of Canada and Montreal. Here are some top favorites to whet your appetite until you can taste it yourself in 2024.

Join us in celebrating Montreal cuisine by showing us your own dish inspired by these favorites. Post your photos on social media using these hashtags #ISMB2020 and #ISMB2020virtualeats and tag @iscb and @meetmontreal for each day’s challenge!

COSI Tracks & Other Abstracts

ISCB MEMBER FEES - Virtual Tutorials
Tutorial 1 will be held on two mornings
Tutorials 2 - 7 will be held on one morning
All times Eastern Daylight Time

High Income Countries Middle-Low Income Countries Low Income Countries
Student (Tutorial 1) $100.00 $50.00 $20.00
Post Doc (Tutorial1) $100.00 $50.00 $20.00
Professional: Academic; Non-profit; Government; or Corporate (Tutorial 1) $100.00 $50.00 $20.00
Student (Tutorials 2 - 7) $50.00 $25.00 $10.00
Post Doc (Tutorials 2 - 7) $50.00 $25.00 $10.00
Professional: Academic; Non-profit; Government; or Corporate (Tutorials 2 - 7) $50.00 $25.00 $10.00
NON-MEMBER FEES - Virtual Tutorials
(fee includes 1 year ISCB membership)

Tutorial 1 will be held on two mornings
Tutorials 2 - 7 will be held on one morning
All times Eastern Daylight Time
High Income Countries Middle-Low Income Countries Low Income Countries
Student (Tutorial 1) $165.00 $85.00 $35.00
Post Doc (Tutorial1) $195.00 $85.00 $35.00
Professional: Academic; Non-profit; Government; or Corporate (Tutorial 1) $240.00 $105.00 $55.00
Student (Tutorials 2 - 7) $110.00 $55.00 $25.00
Post Doc (Tutorials 2 - 7) $140.00 $55.00 $25.00
Professional: Academic; Non-profit; Government; or Corporate (Tutorials 2 - 7) $185.00 $75.00 $40.00

Exhibitors and Recruiters

International Society for Computational Biology
ISCB
www.iscb.org

The International Society for Computational Biology (ISCB) (www.iscb.org) was the first and continues to be the only society representing computational biology and bioinformatics worldwide. ISCB serves a global community of nearly 3,400 scientists dedicated to advancing the scientific understanding of living systems through computation by:

  • convening the world’s experts and future leaders in top conferences
  • partnering with publications that promote discovery and expand access to computational biology and bioinformatics
  • delivering valuable information about training, education, employment, and relevant news
  • providing an influential voice on government and scientific policies that are important to our members

ISCB has three official journals – OUP Bioinformatics, PLOS Computational Biology and F1000Research ISCB Community Journal, and has affiliations in place with several other publications for the benefit of our members.

ISCB Student Council
ISCB www.iscbsc.org

ISCB Student Council (SC, www.iscbsc.org) is an international network of young researchers in the broader disciplines of the field of Computational Biology. SC provides opportunities for networking, career enhancement and skills development for the next generation of Computational Biology leaders. The SC Symposium (symposium.iscbsc.org) is organized as a part of the annual ISMB conference with student presentations, keynotes, panel discussions and a poster session. Come visit our friendly SC representatives at the booth for more information.

GOBLET
GOBLET www.mygoblet.org

GOBLET, the Global Organisation for Bioinformatics Learning, Education and Training, is a legally registered foundation whose mission is to cultivate the global bioinformatics trainer community, set standards and provide high-quality resources to support learning, education and training. GOBLET main objectives are: for the training portal to become both a pull mechanism and repository; to offer training for trainers and end-users; to develop training material and course standards; to provide training resources (surveys, best-practice guidelines, etc.); to raise funds to be able to meet our objectives; to offer a network/community forum; to give further consideration to mechanisms for trainer recognition.

F1000Research
F1000Research f1000research.com

F1000Research is an Open Research publishing platform for scientists, scholars and clinicians offering rapid publication of articles and other research outputs without editorial bias. All articles benefit from transparent peer review and editorial guidance on making all source data openly available.

National Institutes of Health Office of Data Science Strategy
National Institutes of Health Office of Data Science Strategy https://datascience.nih.gov/

The mission of the NIH Office of Data Science Strategy (ODSS) is to catalyze new capabilities in biomedical data science by providing trans-NIH leadership and coordination for modernization of the NIH data resource ecosystem, development of a diverse and talented data science workforce, and building strategic partnerships to develop and disseminate advanced technologies and methods.

Oxford University Press
Oxford University Press https://academic.oup.com/BIOINFORMATICS

Oxford University Press publishes a range of computational biology journals, including Bioinformatics, GigaScience, Nucleic Acids Research, Database, Briefings in Bioinformatics, Briefings in Functional Genomics, and more. Cailin Deery, the publisher for Bioinformatics is exhibiting on behalf of OUP during ISMB this year. Bioinformatics publishes the highest quality scientific papers and review articles with its main focus is on new developments in genome bioinformatics and computational biology. To say hello, ask a question, provide feedback or otherwise, please don’t hesitate to get in touch through the conference scheduling tool.

Recruiters

THE JACKSON LABORATORY
THE JACKSON LABORATORY https://www.jax.org/

JAX uniquely amplifies the efforts of the global biomedical research community. We develop and share our research, innovative tools and solutions, ever‑expanding data resources, more than 11,000 specialized mouse models and services, and a suite comprehensive educational programs to empower basic scientific research and speed drug discovery across the globe.

Career Center

Details about Posting Jobs, Recruiters and the Career Fair are for forthcoming. Please check back soon.

Exclusively for members

  • Member Discount

    ISCB Members enjoy discounts on conference registration (up to $150), journal subscriptions, book (25% off), and job center postings (free).

  • Why Belong

    Connecting, Collaborating, Training, the Lifeblood of Science. ISCB, the professional society for computational biology!

     

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