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Conference on Semantics in Healthcare and Life Sciences

TECH TALKS

Updated Feb 27, 2014


Indicates that presentation slides or other resources are available.

Tech Talks showcase products and services of relevance to the CSHALS audience. Each Tech Talk is 20 minutes (15 minutes presentation and up to 5 minutes for Q&A) in length and designed to allow organizations to create awareness of new technologies, services, etc., in an informational presentation format.

For organizations interested in presenting a Tech Talk, please go to our Sponsor Opportunities page (click here) for further information.

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TECH TALK 1
Thursday, February 27
11:15 am – 11:35 am

High Availability and Graph Mining using bigdata® - an Open-Source Graph Database


- Click here for PDF of presentation.

Presenter: Bryan Thompson, SYSTAP LLC., Greensboro, NC United States



Abstract:  bigdata(R) is a high performance, scalable, open source graph database platform supporting the RDF data model and edge attributes. I will provide a brief overview of the bigdata platform, summarize some of its key differentiators, including the High-Availability enterprise deployment model, an API for writing graph mining algorithms against RDF data, and efficient representation and query of edge attributes, discuss approaches for combining bigdata clusters with map/reduce processing, and provide a glimpse of new features in our roadmap, including accelerated graph processing on GPUs at 3-billion edges per second.

SYSTAP, LLC leads the development of the bigdata open source platform and offers consulting services related scalable information architectures and services and support for the bigdata platform. Bigdata is available under both open source and commercial licenses.

Biography: Bryan Thompson (SYSTAP, LLC) is the Chief Scientist and co-Founder of SYSTAP, LLC. He is the lead architect for bigdata®, an open source graph database used by Fortune 500 companies including EMC (SYSTAP provides the graph engine for the topology server used in their host and storage management solutions) and Autodesk (SYSTAP provides their cloud solution for graph search). He is the principle investigator for a DARPA research team investigating GPU-accelerated distributed architectures for graph databases and graph mining. He has over 30 years experience related to cloud computing; graph databases; the semantic web; web architecture; relational, object, and RDF database architectures; knowledge management and collaboration; artificial intelligence and connectionist models; natural language processing; metrics, scalability studies, benchmarks and performance tuning; decision support systems.
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TECH TALK 2
Thursday, February 27
11:40 am – 12:00 pm

Successfully Navigating Diagnosis And Treatment In The Age Of Targeted Cancer Therapy

Presenter: Helena Deus from Foundation Medicine, Cambridge, United States



Abstract: Initially, cancer was understood in simple terms as a disease caused uncontrolled division of abnormal cells which formed tumors that could "metastasize" to invade other tissues and organs in the body. We knew that certain factors played a role in the cause of cancer like environment, lifestyle, genetic and carcinogens. But we didn't have a clear idea on how cancer was caused or what drove it.

The traditional paradigm for solid tumor treatment was:

  1. To visually examine a tumor biopsy under a microscope to determine if cancer is present, the type of cancer and how advanced or what stage the cancer is in
  2. Traditional cancer treatments include Surgery, Radiation and Traditional Chemotherapy
  3. These are still the mainstay of cancer treatment and while they are highly effective in some patients, they are less effective in others and can cause significant side effects

Today, we know that cancer is a disease of the genome. We understand that cancer is a result of the carcinogens, and other factors causing changes, or alterations to our DNA. And we know that increase exposure to these factors increases the chance of gene alterations.

In this talk, I will explain the paradigm and complexities of Targeted Cancer Therapy from an IT and knowledge management perspective and how we are addressing those at Foundation Medicine.

Biography:  Dr. Deus is a Senior Scientist at Foundation Medicine. Since 2005 she has worked with oncologists and scientists in finding and developing the best strategies to improve the quality of bioinformatics and translational research solutions. Her main area of expertise is in applying RDF/SPARQL-based technologies to solving difficult data problems in biological domains. With her work on RDFizing the Cancer Genome Atlas and linking it to pubmed, her team won her the 2013 Linked Data Cup (at I-Semantics) and the Semantic Web Challenge - Big Data Track (at ISWC2013).

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TECH TALK 3
Friday, February 28
11:20 am – 11:40 am

Making Sense of Big Data in Pharma

Presenter:  Andreas Matern, Vice President, Disruptive Innovation, Thomson Reuters Life Sciences, MA, United States


Abstract: Big Data is quickly becoming an overused, and poorly understood, term in technology.  This talk will focus on Big Data for the life sciences:  are -omics data the only 'big data'?  What's a practical working definition for Big Data in the Life Sciences and does it differ from other areas where data is analyzed at scale?  What role does visualization have in Big Data?  How do we resolve gaps in life sciences data?  How can we spot trends utilizing aggregated information from disparate data sources, and can we effectively ask questions and monitor the ever growing amount of structured and unstructured content that we have access to?  

Biography: Andreas Matern is the Vice President, Disruptive Innovation for Thomson Reuters Life Sciences.  He and his team devote their efforts to the intersection of content and technology - finding new ways to explore how end users can, without assistance from experts, explore information and find the answers to the questions they are most interested in.  Andreas' background is in molecular genetics, but he has spent the entirety of his professional career involved in bioinformatics, where he has worked for over a decade.  He has worked at LION Bioscience, Teranode and InforSense before coming to work at Thomson Reuters.  

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TECH TALK 4
Friday, February 28
11:45 am – 12:05 pm

Using Supercomputer Architecture for Practical Semantic Web Research in the Life Sciences

Presenter:  Matt Gianni, Cambridge, MA,  United States



Abstract:  YarcData delivers on the promise of big data analytics and semantic technologies by enabling research organizations to discover unknown relationships and hidden patterns in their structured and unstructured data. Within Life Sciences and Healthcare, YarcData can provide solutions to advance research in critical disease areas, improve the ability to rescue drug candidates, and find new targets for existing drugs.
 
We will present a use case by which a major cancer research organization is taking a systems biology approach to understanding the development of cancers. By rapidly bringing together data from Medline, TCGA, Pfam, UniProt, and other sources, the organization could model the growth of cancer cells at the molecular level.
 
All of this research was augmented into one body of interrelated, queryable knowledge, from which researchers could fast-track testing using in-silico hypothesis verification. This resulted in a clear visualization of the connections and associations within the data to help identify promising candidates for new therapies. The solution also overcame typical technical challenges, such as dealing with dynamic datasets, limited performance, and scalability issues as seen with relational data warehouses.
 
YarcData’s innovative, real-time approach to cancer research discovery allows researchers to identify new patterns in the data without any upfront modeling or advance knowledge of the data relationships. When compared to traditional database strategies and investigative laboratory experiments, the time to discovery was significantly reduced, saving months or years of research with a higher probability of success.

Biography:  Matt Gianni is a Life Science Solution Architect at YarcData. Matt is responsible for representing YarcData's solutions from a technical and scientific perspective within the Life Science markets. Matt joins us from IDBS where he focused on delivering data management and software solutions in Life Science, with a particular focus on translational research. Over the past 15 years, Matt focused on accelerating drug discovery using computational technologies and has held key technical roles with Elsevier, Symyx, MDL and Exelixis prior to joining YarcData.


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Conference on Semantics in Healthcare and Life Sciences

CONFERENCE SPONSORS

Updated Feb 12, 2014


BRONZE SPONSORS:



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Conference on Semantics in Healthcare and Life Sciences

Keynote Speaker - Ronald Collette, CISSP

Updated Jan 28, 2014

Chief Information Officer
Foundation Medicine
Cambridge, MA, USA

Presentation Date and Time:
Thursday, February 27 - 9:00 am

Presentation Title:

The Carpenter to the Screw: Well, I Have a Hammer. You Must Be a Nail

Abstract:
Big Data is the buzz word du jour for the media. But this phrase only scratches the surface of the problem-space that the Industry is faced with today. The issues of Fast Data extreme cardinality, disparate data formats, the demand for data mining, are but a few of the challenges that call for new approaches. A host of technologies from RDF to NLP hold tremendous promise in addressing many of these issues. During the presentation Ron will discuss the evolution, adoption, and state of computer science within Industry from the perspective of an applied engineer; and address some of the limiting factors that are hindering the adoption of Semantic Technologies.

Biography:
From Punch Cards to Big Data, Mr. Collette has spent the better part of 3 decades working in the field of technology. During that time he has worked with in industries that encompass the various sectors aerospace, engineering, construction, finance, cyber security, life sciences, commercial food, and various entities within the federal government. This variety of experience, coupled with the innate need constantly push the envelope, has garnered him a reputation of solving difficult technical issues with practical solutions that blend mature and cutting-edge technologies.

Ron Collette is a regular speaker at a number of security and IT related events such as International Standards Organization (ISO) conference, SecureWorld Expo, ISMS, and InfoSeCon. He is also a regular columnist and research analyst for Computer Economics and has co-authored two books on information security. The CISO Handbook: A Practical Guide to Securing Your Company and the companion publication CISO Soft Skills: Securing Organizations Impaired by Employee Politics, Apathy and Intolerant Perspectives.  Both of these books are utilized as course material for a number of post-graduate programs on security leadership.

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Conference on Semantics in Healthcare and Life Sciences

Keynote Speaker - Hilmar Lapp

Updated March 03, 2014

Assistant Director for Informatics
National Evolutionary Synthesis Center (NESCent)
Durham, North Carolina, USA

Presentation Date and Time:
Friday, February 28 - 9:00 am

Presentation Title:
Semantics of and for the Diversity of Life: Opportunities and Perils of Trying to Reason on the Frontier

Click here for presentation slides

Abtsract:

The stunning diversity of life has long been a target of research, resulting in billions of specimens and hundreds of millions of pages of text in the world’s natural history museum collections and libraries. A wealth of literature documents in meticulous the detail the features shared between contemporary and extinct species, their evolutionary history and their ecological properties. Enabling the full power of computation for this constantly growing, yet woefully incomplete body of knowledge faces enormous challenges, but also offers huge opportunities. These include discovery, such as candidate gene hypothesis generation, knowledge integration, such as using the tree of life as a map, and prediction, such as forecasting the effects of environmental change on biodiversity patterns and human health. I will present examples of both obstacles and opportunities for semantics-based technologies to enable computing on our knowledge of the diversity and evolution of life on earth.

Biography:
Hilmar Lapp (@hlapp, http://orcid.org/0000-0001-9107-0714) is the Assistant Director for Informatics at the National Evolutionary Synthesis Center (NESCent). His research interests are in reusable and interoperable software and data, large-scale data integration, and in building open sustainable eScience infrastructure. A biologist by training, he has also more than two decades worth of experience developing software, databases, and other informatics resources. He is co-PI of the NSF-funded Phenoscape project (http://phenoscape.org) on ontological annotation of evolutionary phenotype observations, co-convener of the Biodiversity Information Standards (TDWG) Interest Group on Phylogenetics Standards, senior personnel in the Dryad digital data repository project (http://datadryad.org), and a participant in the Data Integration and Semantics Working Group of DataONE (http://dataone.org).

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Conference on Semantics in Healthcare and Life Sciences

Keynote Speaker - Deborah McGuinness, Ph.D

Updated March 02, 2014

Professor, Computer and Cognitive Science
Founding Director, Rensselaer Polytechnic Institute’s Web Science Research Center
Rensselaer Polytechnic Institute (RPI)
Troy, NY, USA

Presentation Date and Time:
Thursday, February 27 - 1:00 pm

Presentation Title:

Towards Semantic Health Assistants

- Click here for PDF of presentation.

Abstract:  In this presentation we will present a vision of semantically-enabled health assistants.  We will present three examples of semantics in practice in the areas of drug repurposing, mobile health advisors, and population health.  We will highlight where semantic technologies are adding value and also present some remaining challenges.

Biography:  Deborah McGuinness is the Tetherless World Senior Constellation Chair and Professor of Computer and Cognitive Science. She is also the founding director of the Web Science Research Center at Rensselaer Polytechnic Institute. Deborah has been recognized with awards for leadership in Semantic Web research and in bridging Artificial Intelligence (AI) and eScience, significant contributions to deployed AI applications, and extensive service to the AI community. Deborah is a leading authority on the semantic web and has been working in knowledge representation and reasoning environments for over 25 years. Deborah's primary research thrusts include work on explanation, trust, ontologies, escience, open data, and semantically-enabled schema and data integration. Prior to joining RPI, Deborah was the acting director of the Knowledge Systems, Artificial Intelligence Laboratory and Senior Research Scientist in the Computer Science Department of Stanford University, and previous to that she was at AT&T Bell Laboratories.

Deborah is also widely known for her leading role in the development of the W3C Recommended Web Ontology Language (OWL), her work on earlier description logic languages and environments, including the CLASSIC knowledge representation system, and more recently, her work on provenance languages and environments, including InferenceWeb, PML, and PROV. She has built and deployed numerous ontology environments and ontology-enhanced applications, including some that have been in continuous use for over a decade at AT&T and Lucent, and two that have won deployment awards for variation reduction on plant floors and interdisciplinary virtual observatories. Recent application thrusts include health informatics and smart environmental monitoring. Some current and recent projects can be explored at http://tw.rpi.edu/web/person/Deborah_L_McGuinness/Projects. She has published over 200 peer-reviewed papers and has authored granted patents in knowledge based systems, ontology environments, configuration, and search technology.

Deborah also consults with clients wishing to plan, develop, deploy, and maintain semantic web and/or AI applications. Some areas of recent work include: data science, next generation health advisors, ontology design and evolution environments, semantically-enabled virtual observatories, semantic integration of scientific data, context-aware mobile applications, search, eCommerce, configuration, and supply chain management. She is a frequent technology advisory board member, currently with Qualcomm, OrbMedia, SocialWire, and Sandpiper Software. She also advised Applied Semantics, Guru Worldwide, and Cerebra prior to their acquisitions. Deborah has also worked as an expert witness in a number of cases, and has deposition and trial experience. Deborah received her Bachelors degree in Math and Computer Science from Duke University, her Masters degree in Computer Science from University of California at Berkeley, and her Ph.D. in Computer Science from Rutgers University.

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Conference on Semantics in Healthcare and Life Sciences

NEWS



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Conference on Semantics in Healthcare and Life Sciences

FULL AGENDA

Updated March 04, 2014


go directly to :[Thursday - February 27] [Friday - February 28]

Indicates that presentation slides or other resources are available.

 

WEDNESDAY, February 26
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TIME EVENT LOCATION
11:00 a.m. - 1:00 p.m. Registration Carver Foyer
1:00 p.m. - 3:00 p.m. Tutorial:
Enterprise and Scientific Data Sharing using Callimachus
Presenter: Dr. David Wood,
3 Round Stones Inc.

Click here for presentation slides
Carver 1
3:00 p.m. - 3:15 p.m. Break Carver Foyer
3:15 p.m. - 5:00 p.m. Tutorial continues Carver 1
4:00 p.m. - 7:00 p.m. Registration Carver Foyer
4:00 p.m. - 5:00 p.m. Poster (Author) Set-up Carver 2 & 3
5:00 p.m. - 6:30 p.m. Poster Reception Carver 2 & 3

THURSDAY, February 27
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
TIME EVENT LOCATION
7:30 a.m. - 10:00 a.m. Registration Carver Foyer
8:00 a.m. - 8:45 a.m. Breakfast (continental) Carver 2 & 3
8:45 a.m. - 9:00 a.m. Welcome & Overview
- Bonnie Berger
ISCB Board Member
- Jonas Almeida
Conference Chair
- Ted Slater
Conference Chair
Carver 1
9:00 a.m. - 10:00 a.m. Keynote Presentation
RON COLLETTE

The Carpenter to the Screw: Well, I Have a Hammer.
You Must Be a Nail
Carver 1
10:05 a.m. - 10:55 a.m. Health Analytics
Lattices for Representing and Analyzing Organogenesis
Presenters: Chimezie Ogbuji, Metacognition LLC, United States
Rong Xu, Case Western University, United States

Click here for PDF of presentation
Carver 1
A Semantic-driven Surveillance Model to Enhance Population Health Decision-making
Presenters: Anya Okhmatovskaia, Arash Shaban-Nejad, and David L. Buckeridge (28)

Click here for PDF of presentation
Carver 1
10:55 a.m. - 11:15 a.m. Break Carver 2 & 3
11:15 a.m. - 11:35 a.m. Tech Talk 1
High Availability and Graph Mining using bigdata® - an Open-Source Graph Database
Presenter: Bryan Thompson, SYSTAP LLC

Click here for PDF of presentation.
Carver 1
11:40 p.m. - 12:00 p.m. Tech Talk 2
Successfully Navigating Diagnosis And Treatment In The Age Of Targeted Cancer Therapy
Presenter: Helena Deus, Foundation Medicine
Carver 1
12:00 p.m. - 1:00 p.m. Lunch Carver 2 & 3
1:00 p.m. - 2:00 p.m. Keynote Presentation
DEBORAH MCGUINNESS

Towards Semantic Health Assistants

Click here for PDF of presentation
Carver 1
2:05 p.m. - 2:55 p.m. Interoperability in Healthcare
Towards Semantic Interoperability of the CDISC Foundational Standards
Presenters: Scott Bahlavooni, Geoff Low and Frederik Malfait

Click here for PDF of presentation
Carver 1
Therapeutic Areas Ontology for Study Data
Presenters: Eric Prud'Hommeaux, Charles Mead and Sajjad Hussain (22)
Carver 1
2:55 p.m. - 3:20 p.m. Break Carver 2 & 3
3:20 p.m. - 4:35 p.m Linked Data
The RDF Platform of the European Bioinformatics Institute
Presenters: Andrew M. Jenkinson, Simon Jupp, Jerven Bolleman, Marco Brandizi, Mark Davies, Leyla Garcia, Anna Gaulton, Sebastien Gehant, Camille Laibe, James Malone, Nicole Redaschi, Sarala M. Wimalaratne, Maria Martin, Helen Parkinson and Ewan Birney (11)

Click here for PDF of presentation
Carver 1
PubChemRDF: Towards a semantic description of PubChem
Presenters: Gang Fu, Bo Yu,
Evan Bolton
Carver 1
Evolving from Data-analytics to Data-applications: How Modular Software Environments Built on Semantic Linked-Data Enable a New Generation of Collaborative Life-Science Applications
Presenters: David King and Robert McBurney (20)
Carver 1
4:35 p.m. - 5:00 p.m. Daily Closing Remarks
Jonas Almeida & Ted Slater, Conference Chairs
Carver 1
FRIDAY, February 28
. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . .
TIME EVENT LOCATION
7:30 a.m. - 10:00 a.m. Registration Carver Foyer
8:00 a.m. - 8:45 a.m. Breakfast (continental) Carver 2 & 3
8:45 a.m. - 9:00 a.m. Review - Previous Day
Jonas Almeida & Ted Slater, Conference Chairs
Carver 1
9:00 a.m. - 10:00 a.m. Keynote Presentation
HILMAR LAPP

Semantics of and for the Diversity of Life: Opportunities and Perils of Trying to Reason on the Frontier

Click here for presentation slides
Carver 1
10:05 a.m. - 10:55 a.m. Semantics in Pharma
The Open PHACTS Project:Progress and Future Sustainability
Presenters: Tom Plasterer, Lee Harland and Bryn Williams-Jones (7)

Click here for PDF of presentation
Carver 1
Safety Information Evaluation and Visual Exploration
(“SIEVE”)
Presenters: Suzanne Tracy, Stephen Furlong, Robert Stanley, Peter Bogetti, Jason Eshleman and Michael Goodman (16)


Click here for PDF of presentation
Carver 1
10:55 a.m. - 11:20 a.m. Break Carver 2 & 3
11:20 a.m. - 11:40 a.m. Tech Talk 3
Making Sense of Big Data in Pharma
Presenter: Andreas Matern
Thomson Reuters Life Sciences
 
11:45 a.m. - 12:05 p.m. Tech Talk 4
Using Supercomputer Architecture for Practical Semantic Web Research in the Life Sciences
Presenter: Matt Gianni, YarcData
 
12:05 p.m. - 1:00 p.m. Lunch Carver 2 & 3
1:00 p.m. - 2:00 p.m. Keynote Presentation
BAREND MONS

Semantics Based Biomedical Knowledge Search, Integration and Discovery
Carver 1
2:05 p.m. - 2:55 p.m. Discovery Infrastructure
Scalable Ontological Query Processing over Semantically Integrated Life Science Datasets using MapReduce
Presenters: Hyeongsik Kim and Kemafor Anyanwu (18)

Click here for PDF of presentation
Carver 1
Multi-Domain Collaboration for Web-Based Literature Browsing and Curation
Presenters: David H. Mason, Marie-Jean Meurs, Erin McDonnell, Ingo Morgenstern, Carol Nyaga, Vahé Chahinian, Greg Butler, Adrian Tsang (9)
 
2:55 p.m. - 3:10 p.m. Break Carver 2 & 3
3:10 p.m. - 4:00 p.m. Improving Scientific Information Sharing by Fostering Reuse of Presentation Material
Presenters: Bernadette Hyland, David Wood, Luke Ruth, James Leigh (6)

Click here for presentation slides
Carver 1
***AWARDED BEST PAPER***

GenomeSnip: Fragmenting the Genomic Wheel to Augment Discovery in Cancer Research

Presenters: Maulik R. Kamdar, Aftab Iqbal, Muhammad Saleem, Helena F. Deus and Stefan Decker

Click here for PDF of presentation
Carver 1
4:00 p.m. - 4:15 p.m. Future Actions and Conference Closing Remarks
Jonas Almeida & Ted Slater, Conference Chairs
Carver 1
4:15 p.m. Conference Ends Carver 1

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Conference on Semantics in Healthcare and Life Sciences

PHOTOS


Robert Stanley, CEO, IO Informatics presenting the IO Informatics Best Poster Prize to Syed Amad Chan Bukhari, University of New Brunswick, St. John, An Interoperable Framework for Biomedical Image Retrieval and Knowledge Discovery
.................................................................................................
F1000 Poster Prize co-winners Tom Plasterer, AstraZeneca and Simon Rakov, AstraZeneca, BAO Reveal: Assay Analysis Using the BioAssay Ontology and Open PHACTS
.................................................................................................
IO Informatics Best Paper Prize winner Aftab Iqbal, Insight, Centre for Data Analytics, NUI Galway, GenomeSnip: Fragmenting the Genomic Wheel to Augment Discovery in Cancer Research with CSHALS Co-Chair Jonas Almeida, University of Alabama at Birmingham, CSHALS Co-Chair Ted Slater, YarcData, Robert Stanley, CEO IO Informatics, and CSHALS Program Committee Chair Chris Baker, University of New Brunswick, St. John, and IPSNP Computing Inc.
.................................................................................................
F1000 Poster Prize winner Jim McCusker, Rensselaer Polytechnic Institute, and 5AM Solutions, Inc. A Nanopublication Framework for Systems Biology and Drug Repurposing
.................................................................................................
 
 Thank you to our sponsors!
 .................................................................................................
 
ISCB Executive Director Diane Kovats welcoming delegates to CSHALS 2014
 .................................................................................................
 
Foundation Medicine Student Travel Fellowship Awardees
from left to right:  Syed Bukhari, University of New Brunswick, St. John, Helena Deus, CSHALS Organizing Committee Member and Senior Scientist, Foundation Medicine, Justin Lancaster, kwiKBio, Aftab Iqbal, Insight, Centre for Data Analytics, NUI Galway, David Mason, Concordia, Ryota Yamanaka, University of Tokyo, HyeongSik Kim, North Carolina State University. Not shown:  Arash Shaban-Nejab
  .................................................................................................

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