ABOUT THE CONFERENCE

The RECOMB/ISCB Conference on Regulatory and Systems Genomics, with DREAM Challenges is one of the premier annual meetings for computational and experimental scientists in the areas of regulatory genomics and systems biology. The conference will be held at the:

Sheraton Philadelphia Downtown Hotel
201 North 17th Street, Philadelphia, PA 19103

Program activities will begin on Sunday, November 15 beginning at 3:00 pm with DREAM sessions and conclude on Wednesday, November 18, 2015 (late afternoon). 
The conference combines the following areas:

• Regulatory Genomics

• Systems Biology

• DREAM Challenges

The conference presents the latest findings about regulatory and systems genomics, fosters discussion about current research directions, and establishes collaborations that are advancing the development of a systems-level understanding of gene regulation. The conference features keynote, oral, and poster presentations.


TOPIC CATEGORIES:

• Network Visualization and Analysis
• Modeling and recognition of regulatory modules and motifs
• Epigenomics, chromatin state
• Non-coding chromatin state establishment, maintenance, and role in development
• Regulatory non-coding RNAs
• Co-transcriptional, post-transcriptional, and translational regulation
• Regulatory networks
• Genetic, molecular, and phenotypic variation and human disease.
• Cellular signatures of biological responses and disease states
• Mathematical modeling and simulation of biological systems
• Methods for systematic validation of high-throughput biological predictions
• Single-cell biology, proteomics, signaling
• Metabolomics
• Ensemble approaches
• Translational systems biology

Learn more about submitting an abstract.

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CONTACT

Steven Leard
ISCB Conferences Director
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Telephone: +1 780-414-1663

HOTEL ACCOMMODATION

Conference Hotel

The conference will be held at the Sheraton Philadelphia Downtown Hotel
201 North 17th Street, Philadelphia, PA 19103

Room Rate:  $149 per night
Discounted room rate will expire on Monday, 2 November 2015.
Rate includes complimentary internet!

Book Online
Telephone: (215) 448-2000, reference RECOMB/ISCB Conference
Fax: (215) 448-2853

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Welcome to the Eighth Annual RECOMB/ISCB Conference on Regulatory and Systems Genomics, with DREAM Challenges

KEYNOTE SPEAKERS

BONNIE BERGER MIT

TUULI LAPPALAINEN Columbia University

ANDRE LEVCHENKO Yale University

WILLIAM STAFFORD NOBLE University of Washington

STEVE QUAKE Stanford University

MICHAEL SHEN Columbia University

OLGA TROYANSKAYA Princeton University

LESLIE VOSSHALL The Rockefeller University

JULIA ZEITLINGER The University of Kansas School of Medicine

Click here for Keynote Speakers page

The eighth RECOMB/ISCB Conference on Regulatory and Systems Genomics, with DREAM Challenges was recently held at the Sheraton Philadelphia Downtown Hotel. Program highlights are noted below:

ANNOUNCEMENTS

Conference Talks on Video:
Many of the conference talks are now available here.
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Delegates please provide your evaluation comments on the form available here

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Top Reading Papers as selected at RSG 2015 (click here)

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Click here to view the Program Book (pdf)

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TOPIC CATEGORIES:

• Network Visualization and Analysis
• Modeling and recognition of regulatory modules and motifs
• Epigenomics, chromatin state
• Non-coding chromatin state establishment, maintenance, and role in development
• Regulatory non-coding RNAs
• Co-transcriptional, post-transcriptional, and translational regulation
• Regulatory networks
• Genetic, molecular, and phenotypic variation and human disease
• Cellular signatures of biological responses and disease states
• Mathematical modeling and simulation of biological systems
• Methods for systematic validation of high-throughput biological predictions
• Single-cell biology, proteomics, signaling
• Metabolomics
• Ensemble approaches
• Translational systems biology

Learn more about submissions here.

PARTICIPATE IN THE DREAM CHALLENGES
This conference will also feature the ninth annual meeting of the Dialogue for Reverse Engineering Assessments and Methods (DREAM). We invite the scientific community to participate in this year’s DREAM Challenges, which have been designed to focus attention on important questions related to human health. Learn more about the DREAM Challenges.

CONFERENCE LOCATION
This year’s conference will take place on Sunday, Nov 15 (3:00 pm) to Wednesday, Nov 18, 2015 at the Sheraton Philadelphia Downtown Hotel (201 North 17th Street, Philadelphia, PA 19103)

HIGHLIGHTS FROM OUR 2014 CONFERENCE
A selection of videos from our 2014 conference in San Diego is now available. You can also download the 2014 program booklet (pdf) or see the Top Ten Paper Awards.

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CALL FOR ABSTRACTS AND PARTICIPATION IN THE DREAM CHALLENGES

The Eighth Annual RECOMB/ISCB Conference on Regulatory and Systems Genomics, with DREAM Challenges is now accepting submissions of abstracts and responses to the DREAM Challenges. The conference will take place in Philadelphia, Pennsylvania, USA, Sunday, November 15 to Wednesday, November 18, 2015.


Note:  The RECOMB / ISCB RSG DREAM conference is no longer including Full Papers in its submission process. All presentations will be selected from the Abstract Submission with opportunity to publish in the ISCB Community Journal as long-abstracts or full papers.  

SUBMISSIONS AND EVALUATION CRITERIA

This conference is designed to present the latest findings about regulatory and systems genomics, foster discussion about current research directions, and establish new collaborations that will advance the development of a systems-level understanding of gene regulation. Some possible topics include:

• Modeling and recognition of regulatory modules and motifs
• Epigenomics, chromatin state
• Non-coding chromatin state establishment, maintenance, and role in development
• Regulatory non-coding RNAs, transcriptional
• Co-transcriptional, post-transcriptional, and translational regulation
• Regulatory networks
• Genetic, molecular, and phenotypic variation and human disease.
• Cellular signatures of biological responses and disease states
• Mathematical modeling and simulation of biological systems
• Methods for systematic validation of high-throughput biological predictions
• Single-cell biology, proteomics, signaling
• Metabolomics
• Ensemble approaches
• Translational systems biology

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Abstracts

We invite one-page abstracts, including both original unpublished work and work that has been published or accepted for publication by a high-impact journal between January 1 and November 1, 2015.  Unpublished work will be considered for either an oral or poster presentation. Work already accepted for publication will be considered for an oral presentation only. Learn more about submitting an abstract here.

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DREAM Challenges

Best performers in the DREAM9.5 and DREAM10 Challenges will have an opportunity to present their methods at the conference. These challenges focus the scientific community’s attention on key problems related to translational research and the reverse engineering of biological networks. For more information about the DREAM Challenges visit the DREAM Challenges website.
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2014 Top Ten Papers in Regulatory and Systems Genomics

Nominations for the most influential papers in regulatory genomics and systems biology published in 2014 (January 1 through December 31, 2015) will be accepted in the fall of 2015. Details will be available soon. First and last authors of the highest ranking papers will be honored at the upcoming conference and highlighted online.

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2014 - 2015 TOP PAPERS READING LIST

AS SELECTED AT RSG 2015

Papers are not listed in any particular order.

• Quantitative modeling of transcription factor binding specificities using DNA shape, Zhou T, Shen N, Yang L, Abe N, Horton J, Mann RS, Bussemaker HJ, Gordân R, Rohs R. PNAS 2015 Apr 14;112(15):4654-9. PMID: 26103224
• Deconvolving the recognition of DNA shape from sequence, Abe N, Dror I, Yang L, Slattery M, Zhou T, Bussemaker HJ, Rohs R, Mann RS. Cell 2015 Apr 9;161(2):307-18. PMID: 25843630
• A method to predict the impact of regulatory variants from DNA sequence, D. Lee, D.U. Gorkin, M. Baker, B.J. Strober, A.L. Asoni, A.S. McCallion, M.A. Beer. Nat Genet. 2015 Aug;47(8):955-61. PMID: 26075791
• Predicting the sequence specificities of DNA- and RNA-binding proteins by deep learning, Alipanahi B, Delong A, Weirauch MT, Frey BJ. Nat Biotechnol 33(8):831-8. PMID: 26213851
• Inferring interaction type in gene regulatory networks using co-expression data, Khosravi P, Gazestani V, Pirhaji L, Law B, Sadeghi M, Goliaei B , Bader G. Algorithms for Molecular Biology 2015, 10:23. PMID: 26265933
• Computational analysis of cell-to-cell heterogeneity in single-cell RNA-sequencing data reveals hidden subpopulations of cells, Buettner F, Natarajan KN, Casale FP, Proserpio V, Scialdone A, Theis FJ, Teichmann SA, Marioni JC, Stegle O. Nature Biotechnology 33, 155-160, 2015. PMID: 25599176
• Joint annotation of chromatin state and chromatin conformation reveals relationships among domain types and identifies domains of cell type-specific expression, Libbrecht, M. W., Ay, F., Hoffman, M. M., Gilbert, D. M., Bilmes, J. A., & Noble, W. S. Genome research 25(4), 544-557. PMID: 25677182
• Elucidating Compound Mechanism of Action by Network Perturbation Analysis, Woo JH, Shimoni Y, Yang WS, Subramaniam P, Iyer A, Nicoletti P, Rodríguez Martínez M, López G, Mattioli M, Realubit R, Karan C, Stockwell BR, Bansal M, Califano A. Cell/em>.. 2015 Jul 16;162(2):441-51. PMID: 26186195
• Large-scale imputation of epigenomic datasets for systematic annotation of diverse human tissues, Ernst J, Kellis M. Nature Biotechnology/em> 33, 364-376, 2015. PMID: 25690853
• The human splicing code reveals new insights into the genetic determinants of disease, Xiong, H. Y., Alipanahi, B., Lee, L. J., Bretschneider, H., Merico, D., Yuen, R. K., ... & Frey, B. J. Science /em>3347(6218), 1254806. PMID: 25525159
• Integration of genomic data enables selective discovery of breast cancer drivers, Sanchez-Garcia F, Villagrasa P, Matsui J, Kotliar D, Castro V, Akavia UD, Chen BJ, Saucedo-Cuevas L, Rodriguez Barrueco R, Llobet-Navas D, Silva JM, Pe'er D. Cellem> 159(6):1461-7. PMID: 25433701
  
  

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