The 16th annual Pacific Symposium on Biocomputing will take place January 3-7 on the Big Island of Hawaii. This year's paper sessions include personal genomics, microbiome studies, integration of biological and clinical data for translational research, GWAS methods for rare alleles, reverse engineering and synthesis of biomolecular systems and multiscale modeling of biosystems. Registration is open, and travel support is available. Applications for travel support are due September 27, and the poster abstract submission deadline is November 29. See http://psb.stanford.edu for details.