ISCB Accomplishments by a Senior Scientist Award Keynote: Ron Shamir
Blavatnik School of Computer Science
Tel Aviv University
Introduced by: Christine Orengo, ISCB President; University College London, United Kingdom
Time: Wednesday, July 13, 2022 at 8:45 AM - 9:45 AM CDT
Room: Madison Ballroom ABCD (Level Four, Monona Terrace)
Presentation Title: Integration, modularity and network analysis for understanding disease
The availability of large multi-modal biological datasets invites researchers to deepen our understanding in basic science and medicine, with the goal of personalized analysis. While inquiry of each data type separately often provides insights, integrative analysis has the potential to reveal more holistic, systems-level findings. We demonstrate the power of integrated analysis in disease by developing algorithms on several levels, including subtyping based on multiple omics for the same cancer; identifying and ranking driver genes in an individual's tumor based on expression and mutation profiles; and predicting a healthy individual’s future risk of developing cancer based on data from routine periodical checkups. Modularity and network analysis are recurring themes in our studies.
Ron Shamir (PhD, UC Berkeley 1984) is a Sackler professor of Bioinformatics in the Blavatnik School of Computer Science at Tel Aviv University. His group develops algorithms and software tools in bioinformatics for understanding the genome and human disease.
Shamir is the founder and head of the Edmond J. Safra Center for Bioinformatics at Tel Aviv University. He has published more than 300 scientific works, including 17 books and edited volumes, and has supervised more than 60 research students. He participated in the creation of RECOMB and of the Israeli Society of Bioinformatics and Computational Biology. He is a recipient of the Landau Prize in Bioinformatics, the Kadar family prize for excellence in research, and a Fellow of the ISCB and the ACM.