11-16 July, 2020!Hackathon Registration Hackathon Website
Ravinder (Ravi) Abrol - California State University Northridge, CA
Philippe Youkharibache - NCI / NIH, Bethesda, MD
Allissa Dillman - ODSS / STRIDES / NIH, Bethesda, MD
Jiyao Wang - NCBI / NIH, Bethesda, MD
- To develop open source software modules for universal biomolecular interactions analyses with focus on SARS-CoV-2 and other virus proteins.
- To create a sustainable community of developers and designers for continued development of such tools.
Four years ago NCBI started developing iCn3D, a web based software to visualize and analyze molecular structures in 1D/2D/3D (Wang et al. 2020). The collaboration was extended to NCI to tackle immunotherapeutic protein design. The software is open source to invite a community of developers to add modules. We had our first Moonlight hackathon at ISMB 2016 in Orlando that led to an initial 2D visualization functionality as part of a number of projects. Recently, we started a second phase of development towards more in-depth analysis of molecular interactions. With the COVID-19 pandemic, we realized that some of the capabilities for sharing structures and structural analyses with peers, in preprints through URLs could be a valuable mechanism to enable collaborative research between scientists. We are racing to add functionality to broaden analytical capabilities to analyze membrane proteins, cell surface proteins, and to bridge the worlds of sequencing, structure, and function. We also need to make structural information accessible to scientists with little knowledge in structure. The software has integrated the visualization of sequence (1D) and structure (3D) and started on 2D, initially at the ISMB 2016 hackathon. We propose to prototype new functionality on that same hackathon model, this time online at ISMB2020.
There is no registration fee for the hackathon@ISMB beyond your normal ISMB2020 registration fees.